Education & Training
Selected Honors & Awards
- Javitt DC & Sweet RA. Auditory dysfunction in schizophrenia: Integrating clinical and basic features. Nat Rev Neurosci. 2015 Aug 20;16(9):535-50. PMCID: PMC4692466
- Murray PS, Kumar S, DeMichele-Sweet MA, Sweet RA. Psychosis in Alzheimer's disease. Biol Psychiatry. 2014 Apr 1;75(7):542-52. PMID: 24103379 PMCID: PMC4036443
- Shelton MA, Newman JT, Gu H, Sampson AR, Fish KN, MacDonald ML, Moyer CE, DiBitetto JV, Dorph-Petersen KA, Penzes P, Lewis DA, Sweet RA. Loss of microtubule-associated protein 2 immunoreactivity linked to dendritic spine loss in schizophrenia. Biol Psychiatry. 2015 Sep 15;78(6):374-85. PMCID: PMC4520801
- MacDonald ML, Ding Y, Newman J, Hemby S, Penzes P, Lewis DA, Yates NA, Sweet RA. Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia. Biol Psychiatry. 2015 Jun 1;77(11):959-68. PMCID: PMC4428927
- DeMichele-Sweet MAA, Weamer EA, Klei L, Vrana DR, Hollingshead DJ, Seltman HJ, Sims R, Foroud T, Hernandez I, Moreno-Grau S, Trraga L, Boada M, Ruiz A, Williams J, Mayeux R, Lopez OL, Sibille EL, Kamboh MI, Devlin B, Sweet RA. Genetic Risk for Schizophrenia and Psychosis in Alzheimer Disease. Mol Psychiatry, 2017. PMCID: Pending.
New Research in Molecular Psychiatry: MAP2 Function Is Altered in Schizophrenia
Schizophrenia is a polygenic disorder with common, rare, and structural variants. These variants each contribute only a small fraction of overall risk for developing the disease. To improve understanding of synaptic and functional deterioration shared by large proportions of individuals with schizophrenia, scientists including Melanie Grubisha, MD, PhD; Matthew MacDonald, PhD; David Lewis, MD; and Robert Sweet, MD...
New Research in Biological Psychiatry & Cerebral Cortex
Two recent studies from the Department of Psychiatry have enhanced our understanding of the role of cortical GABA neurons in health and disease. In Biological Psychiatry, Pitt Psychiatry investigators analyzed indices of parvalbumin-expressing basket cells axon terminals across regions of the visuospatial working memory network in schizophrenia. A paper published in Cerebral Cortex examines GABA neuron transcript...
Now in JAMA Psychiatry: Synaptic Proteome Alterations in the Primary Auditory Cortex of Individuals with Schizophrenia
Individuals with schizophrenia often exhibit impairments in the processing of auditory sensory information and auditory learning. Previous research has implicated the involvement of synaptic protein networks in the pathology of schizophrenia. The number, type and strength of connections between synapses are governed in large part by complex protein networks. “In order for the synapse to function, many different...
“This summer has been one of the most transformative times of my life”: The 10th Annual Center for Translational Mental Health Research Undergraduate Research Program
This summer marks the 10th year of the Undergraduate Research Fellowship Program, funded by the NIMH Conte Center for Translational Mental Health Research. The competitive 10-week summer program provides undergraduate students studying neuroscience, biology and psychology, among other fields, the opportunity to conduct hands-on, cutting-edge neuroscience research under the mentorship of clinical and basic...