Nadine Melhem, PhD

Nadine Melhem, PhD

Associate Professor of Psychiatry and Clinical and Translational Science

Contact Details

3811 O'Hara St.

Education & Training

Psychiatric Epidemiology, University of Pittsburgh, Graduate School of Public Health
Epidemiology and Biostatistics, American University of Beirut

Selected Honors & Awards

NARSAD Young Investigator Award, Brain & Behavior Research Foundation
John & Nancy Emerling Fund Young Investigator Award, Pittsburgh Foundation
NARSAD Young Investigator Award, Brain & Behavior Research Foundation
Young Investigator Award, American Foundation for Suicide Prevention

Research Interests

Neurobiology of stress & suicide; Peripheral and neural biomarkers; Children, adolescents & young adults
Selected Research Publications & Products
  1. Melhem NM, Porta G, Oquendo M, Zelazny J, Keilp J, Iyengar S, Burke A, Birmaher B, Stanely B, Mann J, Brent D. Severity and variability of depression symptoms predict suicide attempt. JAMA Psychiatry. 2019 Jun;76(6):603-613. PubMed PMID:30810713
  2. Melhem NM, Munroe S, Marsland A, Gray K, Brent D, Porta G, Douaihy A, Laudenslager ML, DePietro F, Diler R, Driscoll H, Gopalan P. Blunted HPA axis activity prior to suicide attempt and increased inflammation in attempters. Psychoneuroendocrinology 2017 Mar;77:284-94. PubMed PMID: 28135675
  3. Melhem NM, Keilp JG, Porta G, Oquendo MA, Burke A, Stanley B, Cooper TB, Mann JJ, Brent DA. Blunted HPA axis activity in suicide attempters compared to those at high risk for suicidal behavior. Neuropsychopharmacology. 2016 May;41(6):1447-56. PubMed PMID: 26450815
  4. Melhem NM, Middleton F, McFadden K, Klei L, Faraone SV, Vinogradov S, Tiobech J, Yano V, Kuartei S, Roeder K, Byerley W, Devlin B, Myles-Worsley M. Copy number variants for schizophrenia and related psychotic disorders in oceanic Palau: risk and transmission in extended pedigrees. Biol Psychiatry. 2011 Dec 15;70(12):1115-21. PubMed PMID: 21982423
  5. Melhem NM, Porta G, Shamseddeen W, Walker Payne M, Brent DA. Grief in children and adolescents breaved by sudden parental death. JAMA Psychiatry. 2011 Sep;68(9):911-919. PubMed PMID: 21893658

Clinical Interests

Stress response and suicide
Selected Clinical Publications & Products
  1. Inventory for Complicated Grief- Revised for Children (ICG-RC). An instrument and screen with established cut-offs developed to measure grief reactions in children. Citation: Melhem NM, Porta G, Walker Payne M, Brent DA. Identifying prolonged grief reactions in children: Dimensional and diagnostic approaches. J Am Acad Child Adolesc Psychiatry 2013 Jun;52(6):599-607. PubMed PMID: 23702449

Education Interests

Mentoring undergraduate and graduate students; Mentoring medical students; Mentoring postdoctoral and visiting fellows