Education & Training
- Volk DW. Role of microglia disturbances and immune-related marker abnormalities in cortical circuitry dysfunction in schizophrenia. Neurobiology of Disease,99:58-65, 2017(11): 1112-1121, 2015
- Volk DW, Huang Y, Edelson JR, Sampson AR, & Lewis DA. Cortical GABA markers identify a molecular subtype of psychotic and bipolar disorders. Psychological Medicine, 46(12):2501-2512, 2016.
- Volk DW, Edelson JR, & Lewis DA. Altered expression of developmental regulators of parvalbumin and somatostatin neurons in the prefrontal cortex in schizophrenia. Schizophrenia Research, 177(1-3):3-9, 2016
- Volk DW, Chitrapu A, Edelson JR, Roman KM, Morocco AE, & Lewis DA. Molecular mechanisms and timing of cortical immune activation in schizophrenia. American Journal of Psychiatry, 172(11): 1112-1121, 2015
- Volk DW, Matsubara T, Li S, Sengupta EJ, Georgiev D, Minabe Y, Sampson A, Hashimoto T, & Lewis DA. Deficits in transcriptional regulators of cortical parvalbumin neurons in schizophrenia. American Journal of Psychiatry, 169(10):1082-1091, 2012
New Research: The Molecular Biology of the Human Brain
Investigators at Pitt Psychiatry have recently published studies in Proceedings of the National Academy of Sciences of the United States of America (PNAS) and Translational Psychiatry on the molecular biology of the human brain. Proceedings of the National Academy of Sciences of the United States of America (PNAS): Diurnal rhythms across the human dorsal and ventral striatum In a paper recently published in...
Psychiatry Residents Present Innovative Research at the Third Annual Psychiatry Research Pathway Symposium
The Psychiatry Research Pathway (PRP) Symposium provides UPMC Western Psychiatric Hospital residents engaged in research the opportunity to present their work to an audience of fellow residents, faculty mentors, and other members of our career development community. This year’s program included a talk from seven residents on their current and/or future research, followed by questions and feedback. Program Director...
Department Researchers Find Higher Activity of the Immune-Regulating NF-κB Signaling Pathway in Schizophrenia
Schizophrenia is a devastating neurodevelopmental disorder, marked by changes in a person’s thinking, emotions, and behavior. A number of brain areas are affected in the illness, including a region called the prefrontal cortex that is important for cognitive control of behavior. A growing body of evidence suggests that the immune system is activated in the prefrontal cortex in schizophrenia, but it is unclear how...
Hot Publication - Lewis & Colleagues
Altered expression of ARP2/3 complex signaling pathway genes in prefrontal layer 3 pyramidal cells in schizophreniaDatta D, Arion D, Roman KM, Volk DW and Lewis DAAmerican Journal of Psychiatry, Published online August 2016Lower dendritic spine density on layer 3 pyramidal cells in the dorsolateral prefrontal cortex (DLPFC) appears to contribute to cognitive dysfunction in schizophrenia, whereas psychosis is...