Thomas K Karikari, PhD
Education & Training
Selected Honors & Awards
- Karikari TK*, Pascoal TA*, Ashton NJ, Janelidze S, Benedet AL, Rodriguez JL, Chamoun M, Savard M, Kang MS, Therriault J, Schll M, Massarweh G, Soucy J-P, Hglund K, Brinkmalm G, Mattsson N, Palmqvist S, Gauthier S, Stomrud E, Zetterberg H, Hansson O, Rosa-Neto P & Blennow K (2020). Blood phosphorylated tau 181 as a biomarker for Alzheimers disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts. Lancet Neurology 19, 422433. https://doi.org/10.1016/S1474-4422(20)30071-5 *Joint first authors
- Karikari TK*, Emersic A*, Vrillon A*, Rodriguez JL, Ashton NJ, Kramberg MG, Dumurgier J, Hourregue C, Cucnik S, Brinkmalm G, Rot U, Zetterberg H, Paquet C & Blennow K (2020). Head-to-head comparison of clinical performance of CSF phospho-tau T181 and T217 biomarkers for Alzheimers disease diagnosis Alzheimers and Dementia, (2021) May;17(5):755-767. doi: 10.1002/alz.12236. Epub 2020 Nov 30. *Joint first authors
- Karikari TK*, Benedet AL*, Ashton NJ*, Lantero Rodriguez J, Snellman A, Surez-Calvet M, Saha-Chaudhuri P, Lussier F, Kvartsberg H, Rial AM, Pascoal TA, Andreasson U, Schll M, Weiner MW, Rosa-Neto P, Trojanowski JQ, Shaw LM, Blennow K & Zetterberg H (2020). Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimers Disease Neuroimaging Initiative. Molecular Psychiatry. https://doi.org/10.1038/s41380-020-00923-z *Joint first authors
The Department of Psychiatry Welcomes Three New Research Faculty Members
Pitt Psychiatry extends a warm welcome to three new research faculty members: Candice Biernesser, PhD, LCSW (Assistant Professor of Psychiatry) Dr. Biernesser earned her PhD from the Department of Behavioral and Community Health Sciences at the University of Pittsburgh School of Public Health, then joined the Pitt Department of Psychiatry as a postdoctoral fellow in the Department’s National Institute of Mental...
Molecular Psychiatry: Astrocyte Biomarker Signatures of Amyloid-β and Tau Pathologies in Alzheimer’s Disease
In Alzheimer’s disease, reactive astrocytes can play an important role in the pathophysiology of the disease. Amyloid-β and tau tangles—the two main pathological hallmarks of Alzheimer’s disease—are associated with astrocyte reactivity. However, knowledge about amyloid-β- and tau-specific contributions to reactive astrocyte biomarkers in patients with Alzheimer’s disease is limited. To improve our understanding of...
Pitt Psychiatry Awarded $33.5M National Institute on Aging Program Project Grant Focused on the Pathological and Clinical Progression of Alzheimer’s Disease
The National Institute on Aging (NIA) has awarded the University of Pittsburgh Department of Psychiatry a Program Project Grant (PPG) renewal for “The role of astrogliosis in aging and the pathological and clinical progression of Alzheimer's disease.” The Alzheimer’s PPG will be led by a multiple principal investigator team including Ann Cohen, PhD (Associate Professor of Psychiatry), Howard Aizenstein, MD, PhD...