Faculty

Thomas Karikari, PhD

Thomas K Karikari, PhD

Assistant Professor of Psychiatry

Contact Details

3811 O'Hara Street
Pittsburgh
 
PA
 
15213
Email

Education & Training

PhD
Neuroscience, University of Warwick
Neuroscience, University of Gothenburg

Professional Affiliations

Committee for Aid in Education in Neurochemistry, International Society for Neurochemistry

Selected Honors & Awards

Best Alzheimer publication Award, Swedish Alzheimer Foundation
Astrup Prize, Nordic Federation for Clinical Chemistry

Research Interests

Pathological changes in the Alzheimer brain; Blood biomarkers for Alzheimers disease diagnosis
Selected Research Publications & Products
  1. Karikari TK*, Pascoal TA*, Ashton NJ, Janelidze S, Benedet AL, Rodriguez JL, Chamoun M, Savard M, Kang MS, Therriault J, Schll M, Massarweh G, Soucy J-P, Hglund K, Brinkmalm G, Mattsson N, Palmqvist S, Gauthier S, Stomrud E, Zetterberg H, Hansson O, Rosa-Neto P & Blennow K (2020). Blood phosphorylated tau 181 as a biomarker for Alzheimers disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts. Lancet Neurology 19, 422433. https://doi.org/10.1016/S1474-4422(20)30071-5 *Joint first authors
  2. Karikari TK*, Emersic A*, Vrillon A*, Rodriguez JL, Ashton NJ, Kramberg MG, Dumurgier J, Hourregue C, Cucnik S, Brinkmalm G, Rot U, Zetterberg H, Paquet C & Blennow K (2020). Head-to-head comparison of clinical performance of CSF phospho-tau T181 and T217 biomarkers for Alzheimers disease diagnosis Alzheimers and Dementia, (2021) May;17(5):755-767. doi: 10.1002/alz.12236. Epub 2020 Nov 30. *Joint first authors
  3. Karikari TK*, Benedet AL*, Ashton NJ*, Lantero Rodriguez J, Snellman A, Surez-Calvet M, Saha-Chaudhuri P, Lussier F, Kvartsberg H, Rial AM, Pascoal TA, Andreasson U, Schll M, Weiner MW, Rosa-Neto P, Trojanowski JQ, Shaw LM, Blennow K & Zetterberg H (2020). Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimers Disease Neuroimaging Initiative. Molecular Psychiatry. https://doi.org/10.1038/s41380-020-00923-z *Joint first authors

Pitt Psychiatry Research Published in Alzheimer's & Dementia

Investigators

Pitt Psychiatry investigators have recently published studies in Alzheimer's & Dementia. Below is a summary of recent original research on neural factors underlying cognitive and depressive symptoms in late life, sleep and rest–activity rhythms across different cognitive aging pathways, and the association between attention-deficit/hyperactivity disorder and Alzheimer’s disease. Altered Triple Network Model...

Thomas Karikari, PhD, and Rebecca Thurston, PhD, Receive University of Pittsburgh Chancellor’s Distinguished Research Awards

Drs. Thomas Karikari and Rebecca Thurston

Congratulations to Thomas Karikari, PhD (Assistant Professor of Psychiatry), and Rebecca Thurston, PhD (Pittsburgh Foundation Chair in Women's Health and Dementia and Professor of Psychiatry, Clinical and Translational Science, Epidemiology and Psychology), who have each received a University of Pittsburgh Chancellor’s Distinguished Research Award! Dr. Karikari, who received an award for distinguished research in...

Nature Medicine: Phospho-tau Serine-262 and Serine-356 as Biomarkers of Pre-tangle Soluble Tau Assemblies in Alzheimer’s Disease

Thomas Karikari, PhD

Neurofibrillary tangles are a defining neuropathological feature of Alzheimer’s disease. Patients with Alzheimer’s disease with little or no quantifiable insoluble brain tau neurofibrillary tangle pathology demonstrate stronger clinical benefits of therapies than those with advanced neurofibrillary tangles. The formation of neurofibrillary tangles can be prevented by targeting the intermediate soluble tau...

Sex Differences in Alzheimer's Disease Blood Biomarkers in a Caribbean Population of African Ancestry: The Tobago Health Study

Thomas Karikari, PhD

Sex Differences in Alzheimer's Disease Blood Biomarkers in a Caribbean Population of African Ancestry: The Tobago Health Study INTRODUCTION: Alzheimer’s disease is increasing in the Caribbean, especially for persons of African ancestry and women. However, studies have mostly utilized surveys without AD biomarkers. METHODS: In the Tobago Health Study (n = 309; 109 women, mean age 70.3 ± 6.6),we assessed sex...

Pitt Psychiatry’s 2024 Research Day, Part I: A Research and Networking Bonanza

Research Day 2024

The 22nd annual Department of Psychiatry Research Day, held on June 13, 2024, was the most highly attended Research Day ever, with 544 faculty members, trainees, and staff gathering at Soldiers & Sailors Memorial Hall & Museum on the University of Pittsburgh campus. Lunchtime Roundtables More than 260 individuals participated in or facilitated one of 19 roundtable discussion groups focused on topics including...