Education & Training
Selected Honors & Awards
- MacDonald ML, Alhassa J, Newman JT, Richard M, Gu H, Kelly RM, Sampson AR, Fish KN, Penzes P, Wills ZP, Lewis DA, Sweet RA. Selective Loss of Smaller Spines in Schizophrenia. American Journal of Psychiatry, In Press.
- MacDonald ML, Ding Y, Newman J, Hemby S, Penzes P, Lewis DA, Yates NA, Sweet RA. Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia. Biol Psychiatry. 2015;77:959-968.
- MacDonald ML, Ciccimaro E, Prakash A, Banerjee A, Seeholzer SH, Blair IA, Hahn CG. Biochemical Fractionation and Stable Isotope Dilution Liquid Chromatography-mass Spectrometry for Targeted and Microdomain-specific Protein Quantification in Human Postmortem Brain Tissue. Mol Cell Proteomics. 2012 Dec;11(12):1670-81.
- MacDonald ML, Eaton M, Dudman T, Konradi K. Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the rat. Biological Psychiatry. 1;57(9):1041-51, 2005.
New Findings on Cocaine-Cue Memory Activation and Extinction May Help Reduce the Likelihood of Cue-Motivated Relapse
One of the greatest challenges associated with treating substance use disorders is the heightened attention users give to drug-associated cues, which can produce intense cravings and lead to relapse. One way to reduce the influence of these cues is through extinction learning, in which the cues are presented when the drug is not available, with the goal of reducing the intensity of the association between cocaine...
Hot Publication - MacDonald et al.
Selective Loss of Smaller Spines in Schizophrenia MacDonald ML, Alhassan J, Newman JT, Richard M, Gu H, Kelly RM, Sampson AR, Fish KN, Penzes P, Wills ZP, Lewis DA and Sweet RA American Journal of Psychiatry, Published online 2017 Deceased density of dendritic spines in adult schizophrenia subjects has been hypothesized to result from increased pruning of excess synapses in adolescence. In vivo imaging studies have...
ACNP Selects Drs. Matthew MacDonald and Fabio Ferrarelli for Travel Awards
Congratulations to Matthew MacDonald, PhD , Assistant Professor of Psychiatry, and Fabio Ferrarelli, MD, PhD , a PGY4 resident in the Psychiatry Research Pathway track, on their receipt of Travel Awards from the American College of Neuropsychopharmacology (ACNP). The researchers were selected for the awards from a pool of 338 submissions received by the organization. The awards will support their participation at...
Matthew MacDonald, PhD Appointed Assistant Professor of Psychiatry Please join is in welcoming Matthew MacDonald, PhD to the University of Pittsburgh Department of Psychiatry faculty. After earning a Bachelor?s degree in Biology from Ogelthorpe University in Atlanta, GA, Dr. MacDonald studied the pathology of bipolar disorder and schizophrenia through mRNA expression in the human brain and peripheral tissue as well...