Matthew L MacDonald, PhD

Assistant Professor of Psychiatry

Contact Details

200 Lorthrop Street

Education & Training

University of Pennsylvania, School of Medicine Pharmacology
University of Pittsburgh School of MedicinePsychiatry

Professional Affiliations

Member, Society for Neuroscience
Member, American Society for Mass Spectrometry

Selected Honors & Awards

NARSAD Young Investigator Award, Brain & Behavior Research Foundation

Research Interests

Schizophrenia; Proteomics
Selected Research Publications & Products
  1. MacDonald ML, Alhassa J, Newman JT, Richard M, Gu H, Kelly RM, Sampson AR, Fish KN, Penzes P, Wills ZP, Lewis DA, Sweet RA. Selective Loss of Smaller Spines in Schizophrenia. American Journal of Psychiatry, In Press.
  2. MacDonald ML, Ding Y, Newman J, Hemby S, Penzes P, Lewis DA, Yates NA, Sweet RA. Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia. Biol Psychiatry. 2015;77:959-968.
  3. MacDonald ML, Ciccimaro E, Prakash A, Banerjee A, Seeholzer SH, Blair IA, Hahn CG. Biochemical Fractionation and Stable Isotope Dilution Liquid Chromatography-mass Spectrometry for Targeted and Microdomain-specific Protein Quantification in Human Postmortem Brain Tissue. Mol Cell Proteomics. 2012 Dec;11(12):1670-81.
  4. MacDonald ML, Eaton M, Dudman T, Konradi K. Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the rat. Biological Psychiatry. 1;57(9):1041-51, 2005.

Education Interests

Mentoring undergraduate and graduate students; Mentoring postdoctoral and resident fellows