Education & Training
Selected Honors & Awards
- Rich MT, Huang YH, Torregrossa MM. Caclineurin promotes neuroplastic changes in the amygdala associated with weakened cocaine-cue memories. J Neurosci. 2020, 40:1344-1354.
- Rich MT, Huang YH, Torregrossa MM. Plasticity at thalamo-amygdala synapses regulates cocaine-cue memory formation and extinction. Cell Rep. 2019, 26:1010-1020.
- Bertholomey ML, Stone K, Lam TT, Bang S, Wu W, Nairn AC, Taylor JR, Torregrossa MM. Phosphoproteomic analysis of the amygdala response to adolescent glucocorticoid exposure reveals G-protein coupled receptor kinase 2 as a target for reducing motivation for alcohol. Proteomes. 2018, 6:41.
- Kirschmann EK, Pollock M, Nagarajan V, Torregrossa MM. Effects of adolescent cannabinoid self-administration in rats on addiction-related behaviors and working memory. Neuropsychopharmacol. 2017, 42: 989-1000.
- Rich MT, Abbott TB, Chung L, Gulcicek EE, Stone KL, Colangelo CM, Nairn AC, Taylor JR, Torregrossa MM. Phosphoproteomic analysis reveals a novel mechanism of CaMKIIa regulation inversely induced by cocaine memory extinction versus reconsolidation. J Neurosci. 2016, 36:7613-7627.
Now in The Journal of Neuroscience: Calcineurin Infusions to the Lateral Amygdala Reduce the Reinstatement of Cocaine-Cue Memories
Treatment for substance use disorders, devastating and pervasive illnesses, are complicated by a high propensity for relapse. Relapse can occur when an individual encounters a familiar stimulus that has, in the past, induced cravings. One strategy for potentially preventing relapse is to weaken these maladaptive memories. Two approaches for doing so include interfering with memory reconsolidation—disrupting the...
New Findings on Cocaine-Cue Memory Activation and Extinction May Help Reduce the Likelihood of Cue-Motivated Relapse
One of the greatest challenges associated with treating substance use disorders is the heightened attention users give to drug-associated cues, which can produce intense cravings and lead to relapse. One way to reduce the influence of these cues is through extinction learning, in which the cues are presented when the drug is not available, with the goal of reducing the intensity of the association between cocaine...
Department Faculty Highlight the Role of Adolescent Sleep and Circadian Rhythm Disruptions in Risk of Substance Use Disorders
Sleep and circadian rhythms, the 24-hour cycles of the body’s physiological processes, are important components of health. Likewise, disruptions in these systems are linked to a number of health conditions, including substance abuse. The developmental changes in sleep and circadian rhythms that occur during adolescence leave teenagers particularly vulnerable to addiction. A review recently published in the journal...
Mary Torregrossa, PhD Appointed Associate Professor by Pitt School of Medicine
Mary Torregrossa, PhD focuses her research on examining the factors that can lead to vulnerability to drug addiction and relapse. Using animal models to understand how drugs of abuse co-opt learning and memory systems, she seeks to identify interventions that target these underlying neurobiologic substrates in an effort to reduce substance use and relapse. Combining behavioral, molecular, and sophisticated self...