Mary M Torregrossa, PhD
Education & Training
Selected Honors & Awards
- Rich MT, Huang YH, Torregrossa MM. Caclineurin promotes neuroplastic changes in the amygdala associated with weakened cocaine-cue memories. J Neurosci. 2020, 40:1344-1354.
- Rich MT, Huang YH, Torregrossa MM. Plasticity at thalamo-amygdala synapses regulates cocaine-cue memory formation and extinction. Cell Rep. 2019, 26:1010-1020.
- Bertholomey ML, Stone K, Lam TT, Bang S, Wu W, Nairn AC, Taylor JR, Torregrossa MM. Phosphoproteomic analysis of the amygdala response to adolescent glucocorticoid exposure reveals G-protein coupled receptor kinase 2 as a target for reducing motivation for alcohol. Proteomes. 2018, 6:41.
- Kirschmann EK, Pollock M, Nagarajan V, Torregrossa MM. Effects of adolescent cannabinoid self-administration in rats on addiction-related behaviors and working memory. Neuropsychopharmacol. 2017, 42: 989-1000.
- Rich MT, Abbott TB, Chung L, Gulcicek EE, Stone KL, Colangelo CM, Nairn AC, Taylor JR, Torregrossa MM. Phosphoproteomic analysis reveals a novel mechanism of CaMKIIa regulation inversely induced by cocaine memory extinction versus reconsolidation. J Neurosci. 2016, 36:7613-7627.
Pitt Psychiatry News from the 2022 American College of Neuropsychopharmacology Annual Meeting
Many Pitt Psychiatry faculty and trainees traveled to Phoenix—or participated remotely—for the 2022 American College of Neuropsychopharmacology (ACNP) annual meeting in early December! Below is Pitt Psychiatry news from the meeting: President’s Plenary Marta Peciña, MD, PhD (Associate Professor of Psychiatry), was selected as a President’s Plenary presenter, and discussed the latest work on endogenous opioid...
Bridgeside Labs Addiction Research: Molecular Psychiatry, The Journal of Neuroscience, & Psychopharmacology
The Huang, McClung, and Torregrossa Labs at the University of Pittsburgh’s Bridgeside Point II facility are part of the Department of Psychiatry’s Translational Neuroscience Program, which seeks to understand the neurobiological basis for complex human cognitive and emotional functions, and the manner in which alterations in the brain give rise to the types of disturbances in these functions that characterize...
Now in The Journal of Neuroscience: Calcineurin Infusions to the Lateral Amygdala Reduce the Reinstatement of Cocaine-Cue Memories
Treatment for substance use disorders, devastating and pervasive illnesses, are complicated by a high propensity for relapse. Relapse can occur when an individual encounters a familiar stimulus that has, in the past, induced cravings. One strategy for potentially preventing relapse is to weaken these maladaptive memories. Two approaches for doing so include interfering with memory reconsolidation—disrupting the...
New Findings on Cocaine-Cue Memory Activation and Extinction May Help Reduce the Likelihood of Cue-Motivated Relapse
One of the greatest challenges associated with treating substance use disorders is the heightened attention users give to drug-associated cues, which can produce intense cravings and lead to relapse. One way to reduce the influence of these cues is through extinction learning, in which the cues are presented when the drug is not available, with the goal of reducing the intensity of the association between cocaine...