Marta Peciña, MD, PhD
Education & Training
Selected Honors & Awards
- Sikora M., Heffernan J., Avery E., Mickey B., Zubieta J.K., Pecina M. Salience Network Functional Connectivity Predictors of Placebo Effects in Major Depression. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Jan;1(1):68-76.
- Pecina M., Bohnert A.S.B., Sikora M., Avery E.T., Langenecker S.A., Mickey B.J., Zubieta J.K.: Association Between Placebo-Activated Neural Systems and Antidepressant Responses. JAMA Psychiatry. 2015. Sep. 30; 72(11):1-8. doi:10.1001/jamapsychiatry.2515.1335.
- Pecina M., Love T., Stohler C., Goldman D, Zubieta JK. Effects of the Mu Opioid Receptor Polymorphism (OPRM1 A118G) on Pain Regulation, Placebo Effects and Associated Personality Trait Measures. Neuropsychopharmacology. 2015 Mar;40(4):957-65.
- Pecina M., Martinez Jauand M., Hodgkinson C., Stohler C., Goldman D, Zubieta JK. FAAHselectively influences placebo effects. Mol Psychiatry. 2014 Mar;19(3):385-91. doi: 10.1038/mp.2013.124. Epub 2013 Sep 17.
- Pecina M, Azhar H, Love TM, Lu T, Fredrickson BL, Stohler CS, Zubieta JK. Personality trait predictors of placebo analgesia and neurobiological correlates. Neuropsychopharmacology. 2013; 38 (4):639-646. PMCID: PMC3572460.
Magnetic Resonance Imaging Predictors of Pharmacotherapy Response in Major Depressive Disorder
Major depressive disorder is among the most prevalent psychiatric disorders, affecting nearly 300 million people worldwide, and exacting a substantial personal, social, and economic toll. Antidepressant treatment typically involves an individualized trial-and-error approach with an inconsistent success rate. Given the negative outcomes associated with depression, there is a pressing need for the development of...
University of Pittsburgh School of Medicine Promotes Marta Peciña, MD, PhD, to Associate Professor of Psychiatry
We are delighted to announce that Marta Peciña, MD, PhD, has been promoted to Associate Professor of Psychiatry by the University of Pittsburgh School of Medicine. Dr. Peciña earned her MD, and her PhD in neuroscience from the University of Navarra in Spain. She completed her psychiatry residency at the University of Navarra Medical Center, and postdoctoral training in neuroimaging at the University of Michigan. In...
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging: μ Opioid Antagonist Naltrexone Partially Abolishes the Antidepressant Placebo Effect and Reduces Orbitofrontal Cortex Encoding of Reinforcement
Clinical trials intended to aid in the development of effective antidepressant medication has been hindered by antidepressant placebo effects. These effects may involve cortical and subcortical endogenous opioid signaling, yet the mechanism through which opioid release affects mood remains unclear. In a recent Biological Psychiatry: Cognitive Neuroscience and Neuroimaging paper, Pitt Psychiatry investigators...
Now in Neuropsychopharmacology: Understanding Contextual Processing of Perception in Depression
In a hundred-year-old film, a man is seen looking at a bowl of soup, then at a child in a coffin, then at a woman on a divan. While the film shows the exact same footage of the man three times, interspersed with the other images, audiences perceived that the man reacted to each scene with separate and distinct facial expressions. This phenomenon suggested that audience interpretations of his expression were...