John F Enwright, PhD
Education & Training
- Enwright Iii JF, Arion D, MacDonald WA, Elbakri R, Pan Y, Vyas G, Berndt A, Lewis DA. Differential gene expression in layer 3 pyramidal neurons across 3 regions of the human cortical visual spatial working memory network. Cereb Cortex. 2022 Feb 1.
- Enwright JF, Lewis DA. Similarities in cortical transcriptome alterations between schizophrenia and bipolar disorder are related to the presence of psychosis. Schizophr Bull. 2021 Aug 21;47(5):1442-1451.
- Enwright Iii JF, Huo Z, Arion D, Corradi JP, Tseng G, Lewis DA. Transcriptome alterations of prefrontal cortical parvalbumin neurons in schizophrenia. Molecular Psychiatry. 2018, Jul; 23(7):1606-1613.
- Arion D, Huo Z, Enwright JF, Corradi JP, Tseng G, Lewis DA.Transcriptome alterations in prefrontal pyramidal cells distinguish schizophrenia from bipolar and major depressive disorders.Biol Psychiatry. 2017 Apr 4. [Epub ahead of print]PMID:28476208
- Enwright JF, Sonapala S, Foglio A, Berry R, Fish KN, Lewis DA. Integrity of parvalbumin neurons and perineuronal nets in the dorsolateral prefrontal cortex of subjects with schizophrenia. Neuropsychopharmacology. 2016 Aug;41(9):2206-14. PMID: 26868058
New Research: Cortical Layer 3 Pyramidal Neurons and Visual Spatial Working Memory
Visual spatial working memory, a core cognitive process, is dependent upon a cortical network composed of multiple nodes, including primary visual, posterior parietal, and dorsolateral prefrontal cortices. Within this network, information essential for proper visual spatial working memory function is transferred via projections furnished by pyramidal neurons located primarily in cortical layer 3. Across the primate...
The American Journal of Psychiatry: Diagnosis- and Cell Type-Specific Mitochondrial Functional Pathway Signatures in Schizophrenia and Bipolar Disorder
Schizophrenia and bipolar disorder share genetic and environmental risk factors, and in some cases, certain clinical features such as cognitive impairments and psychosis. Mitochondrial dysfunction is proposed to contribute to the functional, morphological, and molecular brain alterations that may underlie the common features of these disorders. However, mitochondria are critical for multiple biological processes...
Now in The Journal of Neuroscience: Regional Differences among Pyramidal neurons in the Working Memory Cortical Network
Working memory, the ability to maintain a limited amount of information “in mind” to guide everyday thoughts and behaviors, is a core cognitive process. Its function depends on activity in a network of brain areas distributed across the cerebral cortex. Each of these areas display different patterns of activity while information is being maintained. These differences are correlated with, and might depend on...
Translational Neuroscience Program Faculty Show Circadian Rhythms Regulate Reward through Metabolic Signaling in the Brain
Circadian rhythms are near 24-hour oscillations controlling many aspects of physiology and behavior. The coordination and orchestration of these rhythms maintain homeostasis throughout the body. Evidence from humans suggests disruptions to circadian rhythms and sleep are linked to several psychiatric disorders, including substance use and abuse disorders. Indeed, several human and animal studies have demonstrated...