Education & Training
Selected Honors & Awards
- Fu JM, Satterstrom FK, Peng M, Brand H, Collins RL, Dong S, Wamsley B, Klei L, Wang L, Hao SP, Stevens CR, Cusick C, Babadi M, Banks E, Collins B, Dodge S, Gabriel SB, Gauthier L, Lee SK, Liang L, Ljungdahl A, Mahjani B, Sloofman L, Smirnov AN, Barbosa M, Betancur C, Brusco A, Chung BHY, Cook EH, Cuccaro ML, Domenici E, Ferrero GB, Gargus JJ, Herman GE, Hertz-Picciotto I, Maciel P, Manoach DS, Passos-Bueno MR, Persico AM, Renieri A, Sutcliffe JS, Tassone F, Trabetti E, Campos G, Cardaropoli S, Carli D, Chan MCY, Fallerini C, Giorgio E, Girardi AC, Hansen-Kiss E, Lee SL, Lintas C, Ludena Y, Nguyen R, Pavinato L, Pericak-Vance M, Pessah IN, Schmidt RJ, Smith M, Costa CIS, Trajkova S, Wang JYT, Yu MHC; Autism Sequencing Consortium (ASC); Broad Institute Center for Common Disease Genomics (Broad-CCDG); iPSYCH-BROAD Consortium, Cutler DJ, De Rubeis S, Buxbaum JD, Daly MJ, Devlin B, Roeder K, Sanders SJ, Talkowski ME. Rare coding variation provides insight into the genetic architecture and phenotypic context of autism. Nature Genetics doi: 10.1038/s41588-022-01104-0, 2022. PMID: 35982160
- Wang J, Roeder K, Devlin B. Bayesian estimation of cell type-specific gene expression with prior derived from single-cell data. Genome Research 31:1807-1818, 2021. PMID: 33837133
- 229.Klei L, McClain LL, Mahjani B, Panayidou K, De Rubeis S, Grahnat AS, Karlsson G, Lu Y, Melhem N, Xu X, Reichenberg A, Sandin S, Hultman CM, Buxbaum JD, Roeder K, Devlin B. How rare and common risk variation jointly affect liability for autism spectrum disorder. Molecular Autism 12:66, 2021. PMID: 34615521
- Yurko R, GSell M, Roeder K, Devlin B. A selective inference approach for FDR control using multi-omics covariates yields insights into disease risk. Proceedings of the National Academy of Sciences, 117:15028-15035, 2020. PMID: 32522875
- Breen MS, Dobbyn A, Li Q, Roussos P, Hoffman GE, Stahl E, Chess A, Sklar P, Li JB, Devlin B, Buxbaum JD; Common Mind Consortium. Global landscape and genetic regulation of RNA editing in cortical samples from individuals with schizophrenia. Nature Neuroscience 22:1402-1412, 2019. PMID: 31455887
Rare Coding Variation Provides Insight into the Genetic Architecture and Phenotypic Context of Autism
An international consortium of scientists from fields including psychiatry, genetics, genomics, pediatrics, and statistics have published a study in Nature Genetics reporting the discovery of 185 genes significantly associated with autism spectrum disorder (ASD), and more than 300 genes associated with autism or other types of developmental delay. The consortium evaluated genetic data from a cohort of more than 63...
Rare and Common Genetic Variations Confer Liability for Autism Spectrum Disorder
Among scientists working in the field of autism spectrum disorder research, two models represent the most common understanding of the disorder’s genetic underpinnings: one posits that rare risk variants invariably have large impact on liability; the other emphasizes the major role played by common variations with small effects. On a population level, the common variation likely plays the dominant role in liability...
New Research: The Molecular Biology of the Human Brain
Investigators at Pitt Psychiatry have recently published studies in Proceedings of the National Academy of Sciences of the United States of America (PNAS) and Translational Psychiatry on the molecular biology of the human brain. Proceedings of the National Academy of Sciences of the United States of America (PNAS): Diurnal rhythms across the human dorsal and ventral striatum In a paper recently published in...
From the Journal of Abnormal Child Psychology: Heterogeneous Trajectories of Problematic Alcohol Use, Depressive Symptoms, and their Co-Occurrence in Young Adults with and without Childhood ADHD
Are individuals who experience childhood attention deficit hyperactivity disorder (ADHD) at greater risk for co-occurring problematic alcohol use and depressive symptoms in adulthood? In a recent study, researchers including Pitt Psychiatry investigators Frances Wang, PhD, Sarah Pedersen, PhD, Bernie Devlin, PhD, and Brooke Molina, PhD, examined heterogeneity among those with childhood ADHD that could be associated...