Antidepressant Placebo Effects: Endogenous Opioids, Reinforcement Learning, and Beyond


Antidepressant Placebo Effects: Endogenous Opioids, Reinforcement Learning, and Beyond

Marta Peciña, MD, PhD Associate Professor of Psychiatry, University of Pittsburgh School of Medicine

The Department welcomes Marta Peciña, MD, PhD, on December 16, 2022 for our next Meet the PI lecture.

Dr. Peciña is Associate Professor of Psychiatry at the University of Pittsburgh School of Medicine. Her research aims to examine individual differences in mechanisms of antidepressant treatment response in order to identify new targets for therapeutic interventions. In particular, she is interested in understanding how expectancies and learning mechanisms impact mood improvement using placebos as experimental probes. Her lab uses functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) in conjunction with physiological and behavioral measures to investigate how the response to pharmacological treatments can be shaped by expectancies and learning mechanisms. Her findings point to an increased endogenous opioid release in response to expectancies of pain and mood improvement, conferring a key role to the opioid system in the mediation of pain, mood, and positive expectancies.

This is a virtual lecture. To attend via Zoom, click on this link and enter the following:

Meeting ID: 978 0679 2795
Passcode: 241699

For More Information. Please contact Jeanie Knox at

CONTINUING EDUCATION CREDITS. The entirety of this program will be a lecture by the speaker(s). All individuals able to control the content of this educational activity are required to disclose all relevant financial relationships with any proprietary entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients. Registration is not required for this event. This event is free and there will be no refunds. The University of Pittsburgh is an affirmative action, equal opportunity institution. The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The University of Pittsburgh School of Medicine designates this educational activity for a maximum of 1.5 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded .15 continuing education units (CEUs), which are equal to 1.5 contact hours. In accordance with Accreditation Council for Continuing Medical Education requirements on disclosure, information about relationships of presenters with commercial interests (if any) will be included in materials which will be distributed at the time of the conference. WPH is approved by the American Psychological Association to offer continuing education for psychologists. WPH maintains responsibility for this program and its contents. This program is being offered for 1.5 continuing education credits. The indicated number of clock hours of continuing education is provided through UPMC Western Psychiatric Hospital’s Office of Educational Resources and Planning, a PA-approved provider of social work continuing education in accordance with all the applicable educational and professional standards of the Pennsylvania State Board of Social Workers, Marriage and Family Therapist. These clock hours satisfy requirements for LSW/LCSW, LPC and LMFT renewal. For more information, call (412) 204-9085.