Zachary Z Freyberg, MD, PhD

Associate Professor of Psychiatry and Cell Biology

Contact Details

3811 O'Hara St.

Education & Training

Albert Einstein College of Medicine
Developmental & Molecular Biology, Albert Einstein College of Medicine
Psychiatry, Payne Whitney Clinic of New York Presbyterian Hospital, Cornell University
Schizophrenia Research, Columbia University

Specialty Certifications

Board Certification
American Board of Psychiatry and Neurology

Professional Affiliations

Member, Society for Neuroscience
Member, Genetics Society of America
Member, Schizophrenia International Research Society

Selected Honors & Awards

A.E. Bennett Award for Basic Research, Society of Biological Psychiatry
Rising Star Research Award, Pittsburgh Foundation
Leon Levy Foundation Investigator Award, Leon Levy Foundation

Research Interests

Activity-dependent local translation in Alzheimers; Dopamine neuron vulnerability; aging & Parkinson's; Antipsychotic drug-induced metabolic syndrome
Selected Research Publications & Products
  1. Freyberg Z, Aslanoglou D, Shah R, Ballon JS. Intrinsic and Antipsychotic Drug-Induced Metabolic Dysfunction in Schizophrenia. Front. Neurosci. 2017 July; 11:432. doi: 10.3389/fnins.2017.00432.
  2. McCarthy M, Freyberg Z. Dopamine D2 Receptors and the Circadian Clock Reciprocally Mediate Antipsychotic Drug Metabolic Disturbances. npj Schizophrenia 2017 Apr; 3(17): doi:10.1038/s41537-017-0018-4. PubMed PMID: 28560263.
  3. Freyberg Z, Sonders MS, Aguilar JI, Hiranita T, Karam CS, Flores J, Pizzo AB, Zhang Y, Farino ZJ, Chen A, Martin CA, Kopajtic TA, Fei H, Hu G, Lin YY, Mosharov EV, McCabe BD, Freyberg R, Wimalasena K, Hsin LW, Sames D, Krantz DE, Katz JL, Sulzer D, Javitch JA. Mechanisms of amphetamine action illuminated through in vivo optical monitoring of dopamine synaptic vesicles. Nature Communications 2016 Feb 16; 7:10652 doi: 10.1038/ncomms10652. PubMed PMID: 26879809.
  4. Farino ZJ, Morgenstern TJ, Vallaghe J, Gregor N, Donthamsetti P, Harris PE, Pierre N, Freyberg R, Charrier-Savournin F, Javitch JA, Freyberg Z. Development of a homogenous time-resolved fluorescence assay for rapid insulin measurement. PLoS ONE 2016 Feb 5; 11(2): e0148684. PubMed PMID: 26849707.
  5. Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel RL, Harris PE. Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro. Mol Endocrinol. 2012 Oct; 26(10): 1757-1772. PubMed PMID: 22915827.

Clinical Interests

Antipsychotic drug-induced metabolic disorders; Mechanisms of antipsychotic drug actions
Selected Clinical Publications & Products
  1. Freyberg R, Chung CK, Freyberg, Z, Barnhill J, Ferrando S, Pennebaker, JW. The Write Stuff: Relationships between narrative content and psychiatric illness. Narrative Inquiry 2014; 24: 28-39.
  2. Freyberg Z, Ferrando SJ, Javitch JA. Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action. Am J Psychiatry 2010 Apr; 167(4): 388-396. PubMed PMID: 19917593.
  3. APA Work Group on Alzheimer's Disease and other Dementias, Rabins PV, Blacker D, Rovner BW, Rummans T, Schneider LS, Tariot PN, Blass DM; Steering Committee on Practice Guidelines, McIntyre JS, Charles SC, Anzia DJ, Cook IA, Finnerty MT, Johnson BR, Nininger JE, Schneidman B, Summergrad P, Woods SM, Berger J, Cross CD, Brandt HA, Margolis PM, Shemo JP, Blinder BJ, Duncan DL, Barnovitz MA, Carino AJ, Freyberg Z, Gray SH, Tonnu T, Kunkle R, Albert AB, Craig TJ, Regier DA, Fochtmann LJ. Practice guideline for the treatment of patients with Alzheimer's disease and other dementias. Second edition. Am J Psychiatry 2007 Dec; 164 (12 Suppl): 5-56. PubMed PMID: 18340692.
  4. Ferrando SJ, Freyberg Z. Treatment of depression in HIV positive individuals: a critical review. Int Rev Psychiatry 2008 Feb; 20(1): 61-71. PubMed PMID: 18240063.
  5. Floyd S, Butler MH, Cremona O, David C, Freyberg Z, Zhang X, Solimena M, Tokunaga A, Ishizu H, Tsutsui K, De Camilli P. Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer. Mol Med. 1998 Jan; 4(1): 29-39. PubMed PMID: 9513187.

Education Interests

Medical, graduate student & resident education; Research mentorship
Selected Education Publications & Products
  1. Freyberg R, Freyberg Z. Behavioral and Social Sciences. in: Ferrando S, (ed.), Psychiatry-In-Review 2006. Educational Testing and Assessment Systems, NY, NY.
  2. Freyberg Z, Savitz A. Schizophrenia. in Ferrando S, (ed.), Psychiatry-In-Review 2006. Educational Testing and Assessment Systems, NY, NY.
  3. Freyberg Z. Schizophrenia and Violence. in: Barnhill J, (ed.), Approaching the Psychiatric Patient 1st Edition 2008. APA Press, Washington, D.C.