Max E Joffe, PhD
Education & Training
Selected Honors & Awards
- Joffe ME, Maksymetz J, Luschinger JR, Dogra S, Ferranti AS, Luessen DJ, Gallinger IM, Xiang Z, Branthwaite H, Melugin PR, Williford KM, Centanni SW, Shields BC, Lindsley CW, Calipari ES, Siciliano CA, Niswender CM, Tadross MR, Winder DG, Conn PJ. Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons. Neuron. 2022 Jan 13:S0896-6273(21)01044-8. doi: 10.1016/j.neuron.2021.12.027.
- Maksymetz J, Byun NE, Luessen DJ, Li B, Barry R, Gore JC, Niswender CM, Lindsley CW, Joffe ME, Conn PJ. mGlu1 potentiation enhances cortical somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits. Cell Reports. 2021 Nov 2;37(5):109950. doi: 10.1016/j.celrep.2021.109950.
- Joffe ME, Santiago CI, Oliver KH, Maksymetz J, Harris NA, Engers JL, Lindsley CW, Winder DG, Conn PJ. mGlu2 and mGlu3 negative allosteric modulators divergently potentiate thalamocortical transmission and exert rapid antidepressant-like effects. Neuron. 2020 Jan 8;105(1)46-59. pii: S0896-6273(19)30847-5. doi: 10.1016/j.neuron.2019.09.044. Epub 2019 Nov 14.
- Joffe ME, Santiago CI, Engers JL, Lindsley CW, Conn PJ. Metabotropic glutamate receptor subtype 3 gates acute stress-induced dysregulation of amygdala-cortical function. Molecular Psychiatry. 2019 Jun; 24(6):916-927. doi:10.1038/s41380-017-0015-z. Epub 2017 Dec 21.
- Joffe ME and Grueter BA. Cocaine experience enhances thalamo-accumbens N-methyl-D-aspartate receptor function. Biological Psychiatry. 2016 Nov 1;80(9):671-681.
The Department of Psychiatry’s 20th Annual Research Day
The 20th annual Department of Psychiatry Research Day on June 9, 2022, represented a joyful reunion for more than 400 faculty members, trainees, and staff, who had not attended a large in-person event together since 2019. The morning session featured 110 posters at Soldiers & Sailors Memorial Hall & Museum in the Oakland section of Pittsburgh. In the afternoon, attendees gathered across the street at the University...
Neuron: New Research on Acute Stress and the Prefrontal Cortex
Acute stressors affect how we perceive the world, allocate our mental energy, and make decisions. Although the prefrontal cortex is known to be an essential brain region involved in adaptive behaviors related to stress, our understanding of the individual cell types and synaptic plasticity mechanisms in the prefrontal cortex is limited. In a recent study published in Neuron, a team of investigators including co...
The Department of Psychiatry Welcomes New Faculty Members
The Department of Psychiatry extends a warm welcome to four new faculty members: Tiffany Clark, MD (Assistant Professor of Psychiatry) Dr. Clark earned her medical degree from Creighton University School of Medicine. Following psychiatry residency at Temple University, she completed her consultation-liaison fellowship at UPMC Western Psychiatric Hospital (WPH). At the Temple University Hospital Health System, Dr...