Faculty

Max Joffe, PhD

Max E Joffe, PhD

Assistant Professor of Psychiatry

Contact Details

3811 O'Hara St.
Pittsburgh
 
PA
 
15213

Education & Training

PhD
Vanderbilt University Pharmacology
Vanderbilt UniversityPharmacology

Professional Affiliations

Member, Society for Neuroscience
Member, American Society for Pharmacology and Experimental Therapeutics
Member, Research Society on Alcoholism

Research Interests

Prefrontal cortex; interneurons; Novel pharmacology; Alcohol use disorders & affective disorders
Selected Research Publications & Products
  1. Maksymetz J, Byun NE, Luessen DJ, Li B, Barry R, Gore JC, Niswender CM, Lindsley CW, Joffe ME, Conn PJ. mGlu1 potentiation enhances cortical somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits. Cell Reports. In press.
  2. Joffe ME, Santiago CI, Stansley BJ, Maksymetz J, Gogliotti RG, Engers JL, Nicoletti F, Lindsley CW & Conn, PJ. Mechanisms underlying prelimbic prefrontal cortex mGlu3/mGlu5-dependent plasticity and reversal learning deficits following acute stress. Neuropharmacology. 2019 Jan;144:19-28. doi: 10.1016/j.neuropharm.2018.10.013.
  3. Joffe ME, Santiago CI, Oliver KH, Maksymetz J, Harris NA, Engers JL, Lindsley CW, Winder DG, Conn PJ. mGlu2 and mGlu3 negative allosteric modulators divergently potentiate thalamocortical transmission and exert rapid antidepressant-like effects. Neuron. 2020 Jan 8;105(1)46-59. pii: S0896-6273(19)30847-5. doi: 10.1016/j.neuron.2019.09.044. Epub 2019 Nov 14.
  4. Joffe ME, Santiago CI, Engers JL, Lindsley CW, Conn PJ. Metabotropic glutamate receptor subtype 3 gates acute stress-induced dysregulation of amygdala-cortical function. Molecular Psychiatry. 2019 Jun; 24(6):916-927. doi:10.1038/s41380-017-0015-z. Epub 2017 Dec 21.
  5. Joffe ME and Grueter BA. Cocaine experience enhances thalamo-accumbens N-methyl-D-aspartate receptor function. Biological Psychiatry. 2016 Nov 1;80(9):671-681.

Education Interests

Research mentoring; Graduate & medical student education