Faculty

Kyle D Ketchesin, PhD

Kyle D Ketchesin, PhD

Assistant Professor of Psychiatry

Contact Details

3811 O'Hara St.
Pittsburgh
 
PA
 
15213
Email

Education & Training

PhD
Neuroscience, University of Michigan
Psychiatry, University of Pittsburgh School of Medicine

Professional Affiliations

Member, Society for Neuroscience
Member, Research Society on Alcohol
Member, Society for Research on Biological Rhythms

Selected Honors & Awards

Young Investigator Award, Brain & Behavior Foundation
Hamilton Family Award for Basic Neuroscience Research in Psychiatry, Department of Psychiatry, University of Pittsburgh School of Medicine

Research Interests

Circadian rhythms in psychiatric disorders; Epigenetics; Multi-omics
Selected Research Publications & Products
  1. Perez MS, Yin R, Scott MR, Zong W, Seney ML, Xue X, Hildebrand MA, Shankar VG, Glausier JR, Lewis DA, Tseng GC, Ketchesin KD & McClung CA. (2025). Sex and regional differences in gene expression across the striatum in psychosis. Translational Psychiatry, 15(1):192. doi: 10.1038/s41398-025-03395-3.
  2. Ketchesin KD, Becker-Krail DD, Xue X, Wilson RS, Lam TT, Williams KR, Nairn AC, Tseng GC & Logan RW. (2023). Differential effects of cocaine and morphine on the diurnal regulation of the mouse nucleus accumbens proteome. Journal of Proteome Research, 22(7):2377-2390. doi: 10.1021/acs.jproteome.3c00126.
  3. Ketchesin KD, Zong W, Hildebrand MA, Scott MR, Seney ML, Cahill KM, Shankar VG, Glausier JR, Lewis DA, Tseng GC & McClung CA. (2023). Diurnal alterations in gene expression across striatal subregions in psychosis. Biological Psychiatry, 93(2):137-148. doi: 10.1016/j.biopsych.2022.08.013.
  4. Ketchesin KD, Zong W, Hildebrand MA, Seney ML, Cahill KM, Scott MR, Shankar VG, Glausier JR, Lewis DA, Tseng GC & McClung CA. (2021). Diurnal rhythms across the human dorsal and ventral striatum. Proceedings of the National Academy of Sciences, 118(2):e2016150118. doi: 10.1073/pnas.2016150118.
  5. Ketchesin KD, Becker-Krail D & McClung CA. (2020). Mood-related central and peripheral clocks. European Journal of Neuroscience, 51(1):326-345. doi: 10.1111/ejn.14253.

Pitt Psychiatry’s 2024 Research Day, Part I: A Research and Networking Bonanza

Research Day 2024

The 22nd annual Department of Psychiatry Research Day, held on June 13, 2024, was the most highly attended Research Day ever, with 544 faculty members, trainees, and staff gathering at Soldiers & Sailors Memorial Hall & Museum on the University of Pittsburgh campus. Lunchtime Roundtables More than 260 individuals participated in or facilitated one of 19 roundtable discussion groups focused on topics including...

Molecular Psychiatry: Cell-type and Sex-Specific Rhythmic Gene Expression in the Nucleus Accumbens

DePoy and McClung

Circadian rhythms are critical for human health and are highly conserved across species, controlling physiological processes and behavior across the light/dark cycle. In addition to regulating basic physiological processes and brain function, disrupted circadian genes are linked to altered mood and substance use vulnerability. Circadian genes modulate behavior through specific cell types in the nucleus accumbens...

The 2024 Society of Biological Psychiatry Annual Meeting in Austin, TX

Collage of Photos from 2024 SOBP Meeting

The 2024 Society of Biological Psychiatry (SOBP) Annual Meeting was held in Austin, TX. Pitt Psychiatry faculty and trainees gathered for a program that explored whether the translational medicine approach is living up to its promise in psychiatry. The conference additionally presented the opportunity to network and meet up with Pitt Psychiatry friends and alums! Gold Medal Award Mary Phillips, MD, MD (Cantab)...

Pitt Psychiatry News from the 2023 American College of Neuropsychopharmacology Annual Meeting

2023 ACNP Annual Meeting Collage

Many University of Pittsburgh Department of Psychiatry faculty and trainees attended the 2023 American College of Neuropsychopharmacology (ACNP) annual meeting to learn about and present new research, and connect with colleagues. Below is a recap of Pitt Psychiatry news from the meeting: Honorific Award Mary Phillips, MD, MD (Cantab) (Distinguished Professor of Psychiatry, Clinical and Translational Science, and...

Biological Psychiatry: Diurnal Alterations in Gene Expression Across Striatal Subregions in Psychosis

Drs. Kyle Ketchesin & Colleen McClung

Psychosis, an impairment that manifests as hallucinations and/or delusions, is a defining feature of schizophrenia and highly prevalent in bipolar disorder. Individuals suffering with these illnesses also have major disruptions in sleep and circadian rhythms, which can precipitate or exacerbate psychotic symptoms. A group of investigators including Kyle Ketchesin, PhD (Assistant Professor of Psychiatry), Madeline...