Howard J Aizenstein, MD, PhD
Education & Training
Selected Honors & Awards
- Karim, H. T., et al. \Intrinsic functional connectivity in late-life depression: trajectories over the course of pharmacotherapy in remitters and non-remitters.\" Molecular psychiatry 22.3 (2017): 450."
- Lim HK, Nebes R, Snitz B, Cohen A, Mathis C, Price J, Weissfeld L, Klunk W & Aizenstein HJ. (2014) Regional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects. Brain. 137: 3327-3338. PMCID: PMC4240287
- Aizenstein HJ, Andreescu C, Edelman KL, Cochran JL, Price J, Butters MA, Karp J, Patel M, & Reynolds CF 3rd. (2011) fMRI correlates of white matter hyperintensities in late-life depression. The American Journal of Psychiatry. 168(10):1075-82. PMCID: PMC3656408
- Aizenstein HJ, Nebes RD, Saxton JA, Price JC, Mathis CA, Tsopelas ND, Ziolko S, James JA, Snitz B, Houck P, Bi W, Cohen A, Lopresti BJ, DeKosky ST, Halligan E, & Klunk WE. (2008) Frequent amyloid deposition without significant cognitive impairment among the elderly. Archives of Neurology. 65(11):1509-17. PMCID: PMC2636844
- Aizenstein HJ, Butters MA, Figurski JL, Meltzer CC, Stenger VA, Reynolds CF 3rd, Carter CS. (2004) Prefrontal and striatal activation during sequence learning in geriatric depression. Presented at the Society for Neuroscience Annual Meeting, San Diego, CA.
New Research in Psychological Medicine and Human Brain Mapping on the Effects of Disrupted Sleep and Early Life Stress in Young People
Psychological Medicine: Experimentally Imposed Circadian Misalignment Alters the Neural Response to Monetary Rewards and Response Inhibition in Healthy Adolescents During adolescence, circadian rhythm and natural sleep and wake times shift later, which can conflict with early school-start times. This incongruence commonly results in circadian misalignment (mismatch between the behavioral sleep-wake schedule and the...
Pitt Psychiatry Investigators Report New Findings in Alzheimer’s Disease and Dementia & Late-Life Depression Research
Acta Neuropathologica: Plasma P-Tau231, A New Biomarker for Incipient Alzheimer's Disease Pathology Scientists including Tharick Pascoal, MD, PhD (Assistant Professor of Psychiatry and Neurology) from Pitt Psychiatry have published the discovery and validation of a new blood biomarker of Alzheimer’s disease which, for the first time, can produce remarkably early detection of the pathology. The quantification of...
Study on Worry and Brain Connectivity in Older Adults Selected as Editor’s Choice in Journal of Affective Disorders
The paper described below was selected as a Journal of Affective Disorders Editor’s Choice. Is worry good for you? According to a study focused on anxiety in older adults, and published in the Journal of Affective Disorders, a moderate level of worry can enhance connectivity among brain regions involved in emotion regulation—while excessive worry yields the inverse effect. Generalized anxiety disorder is common in...
The Department of Psychiatry Announces a New Bioengineering in Psychiatry Predoctoral Training Program
The Department of Psychiatry is pleased to announce a new, interdisciplinary predoctoral training program, supported by the National Institute of Mental Health. The Bioengineering in Psychiatry Training Program will prepare students with backgrounds in engineering and other quantitative sciences for careers in mental health research. The program, which capitalizes on existing University of Pittsburgh research...