Howard J Aizenstein, MD, PhD

Charles F. Reynolds III and Ellen G. Detlefsen Endowed Chair in Geriatric Psychiatry and Professor of Bioengineering and Clinical and Translational Science

Contact Details

3811 O'Hara St.

Education & Training

University of Illinois
Computer Science, University of Illinois
General Psychiatry and Medicine, University of Pittsburgh School of Medicine
General and Adult Psychiatry, Western Psychiatric Institute and Clinic of UPMC
Geriatric Psychiatry, Western Psychiatric Institute and Clinic of UPMC
Geriatric Psychiatry, University of Pittsburgh School of Medicine

Specialty Certifications

Board Certification
American Board of Psychiatry and Neurology (Geriatric Psychiatry)

Current Appointments

Director, Clinical Research Training in Late-Life Mood Disorders
Director, Geriatric Psychiatry Neuroimaging Laboratory
Co-Director, Psychiatry Neuroimaging Program, Department of Psychiatry, University of Pittsburgh School of Medicine

Professional Affiliations

Chair, Research Committee, American Association of Geriatric Psychiatry
Triage Editor, American Journal of Geriatric Psychiatry
Scientific Advisor, American Foundation for Suicide Prevention

Selected Honors & Awards

Pfizer-Eisai Alzheimer's Disease Research Award, American Association of Geriatric Psychiatry
Outstanding Mentorship Award, Western Psychiatric Institute and Clinic of UPMC

Research Interests

Computational psychiatry; Geriatric mental health; Neuroimaging
Selected Research Publications & Products
  1. Karim, H. T., et al. \Intrinsic functional connectivity in late-life depression: trajectories over the course of pharmacotherapy in remitters and non-remitters.\" Molecular psychiatry 22.3 (2017): 450.
  2. Lim HK, Nebes R, Snitz B, Cohen A, Mathis C, Price J, Weissfeld L, Klunk W & Aizenstein HJ. (2014) Regional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects. Brain. 137: 3327-3338. PMCID: PMC4240287
  3. Aizenstein HJ, Andreescu C, Edelman KL, Cochran JL, Price J, Butters MA, Karp J, Patel M, & Reynolds CF 3rd. (2011) fMRI correlates of white matter hyperintensities in late-life depression. The American Journal of Psychiatry. 168(10):1075-82. PMCID: PMC3656408
  4. Aizenstein HJ, Nebes RD, Saxton JA, Price JC, Mathis CA, Tsopelas ND, Ziolko S, James JA, Snitz B, Houck P, Bi W, Cohen A, Lopresti BJ, DeKosky ST, Halligan E, & Klunk WE. (2008) Frequent amyloid deposition without significant cognitive impairment among the elderly. Archives of Neurology. 65(11):1509-17. PMCID: PMC2636844
  5. Aizenstein HJ, Butters MA, Figurski JL, Meltzer CC, Stenger VA, Reynolds CF 3rd, Carter CS. (2004) Prefrontal and striatal activation during sequence learning in geriatric depression. Presented at the Society for Neuroscience Annual Meeting, San Diego, CA."

Clinical Interests

Late-life depression; Dementia

Education Interests

Geriatric mental health research mentorship and tr; Mentoring in translational mental health research; Bioengineering in Psychiatry