Dana L Tudorascu, PhD
Education & Training
- Lopresti BJ, Campbell EM, Yu Z,Anderson SJ,Cohen AD, Minhas DS, Snitz BE,Royse SK,Becker CR, Aizenstein HJ, Mathis CA, Lopez OL, Klunk WE, Tudorascu, DL Influence of apolipoprotein-E genotype on brain amyloid load and longitudinal trajectories, Neurobiology of Aging, May 2020, https://doi.org/10.1016/j.neurobiolaging.2020.05.012, In Press.
- Snitz BE, Tudorascu DL, Yu Z, Campbell E, Lopresti BJ, Laymon CH, Minhas DS, Nadkami NK, Aizenstein JH, Klunk WE, Weintraub S, Gershon RC, Cohen AD. Associations between NIH Toolbox Cognition Battery and in vivo brain amyloid and tau pathology in non-demented older adults. Alzheimers Dement (Amst). 2020;12(1):e12018. Published 2020 May 15. doi:10.1002/dad2.12018, PubMed PMID: 32426450.
- Karim HT, Tudorascu DL, Cohen A, Price JC, Lopresti B, Mathis C, Klunk W, Snitz BE, Aizenstein HJ. Relationship Between Executive Control Circuit Activity, Amyloid Burden, and Education in Cognitively Healthy Older Adults, Am J Geriatric Psychiatry, 2019 Jul 19, pii: S1064-7481(19)30437-3. doi: 10.1016/j.jagp.2019.07.008, PMID:31402087.
Genetic Risk for Attention-Deficit/Hyperactivity Disorder Predicts Cognitive Decline and Development Of Alzheimer’s Disease Pathophysiology in Cognitively Unimpaired Older Adults
Attention-deficit/hyperactivity disorder (ADHD) persists in older age and may be a risk factor for cognitive impairment and Alzheimer’s disease. A recent study published in Molecular Psychiatry aimed to determine whether genetic liability for ADHD, as measured by a well-validated ADHD polygenic risk score, is associated with cognitive decline and the development of Alzheimer’s disease pathophysiology in cognitively...
Molecular Psychiatry: Astrocyte Biomarker Signatures of Amyloid-β and Tau Pathologies in Alzheimer’s Disease
In Alzheimer’s disease, reactive astrocytes can play an important role in the pathophysiology of the disease. Amyloid-β and tau tangles—the two main pathological hallmarks of Alzheimer’s disease—are associated with astrocyte reactivity. However, knowledge about amyloid-β- and tau-specific contributions to reactive astrocyte biomarkers in patients with Alzheimer’s disease is limited. To improve our understanding of...
Pitt Psychiatry Awarded $33.5M National Institute on Aging Program Project Grant Focused on the Pathological and Clinical Progression of Alzheimer’s Disease
The National Institute on Aging (NIA) has awarded the University of Pittsburgh Department of Psychiatry a Program Project Grant (PPG) renewal for “The role of astrogliosis in aging and the pathological and clinical progression of Alzheimer's disease.” The Alzheimer’s PPG will be led by a multiple principal investigator team including Ann Cohen, PhD (Associate Professor of Psychiatry), Howard Aizenstein, MD, PhD...
Recent Research on the Harmonization of Neuroimaging Data Using RAVEL and ComBat
Neuroimaging studies of structural magnetic resonance imaging (MRI) provide invaluable insights into the changes underlying neurodegenerative diseases, such as Alzheimer's disease, but frequently combine data collected from multiple scanners and experimental conditions. These conditions can yield data containing substantial technical variability and biases due to differences in sites, scanners, and image...