Bruna Bellaver, PhD
Research Assistant Professor of Psychiatry
Contact Details
3811 O'Hara St.
Pittsburgh
PA
15213
Email bellaverb@upmc.edu
Education & Training
PhD
Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Psychiatry, University of Pittsburgh School of Medicine
Biochemistry, Federal University of Rio Grande do Sul, Brazil, Porto Alegre, Brazil
Professional Affiliations
Member, ISTAART Alzheimer's Association
Research Interests
Aging & Alzheimer's disease; Neuroimaging biomarkers; Fluid biomarkers
Selected Research Publications & Products- Bellaver B, Povala G, Ferreira PCL, Bauer-Negrini G, Firoza Z. Lussier FZ, Leffa DT, Ferrari-Souza JP, Rodrigues MS, Amaral L, Oliveira MS, Soares C, Rocha A, Saha P, Rahmouni N, Tissot C, Therriault J, Servaes S, Klostranec J, Montembeault M, Benedet AL, Ashton NJ, Koscik RL, Betthauser TJ, Christian BT, Wilson R, Triana-Baltzer G, Vitali P, Gauthier S, Zetterberg H, Blennow K, Karikari TK, Tudorascu D, Zimmer ER, Johnson S, Rosa-Neto P, Pascoal TA (2025). Plasma GFAP for populational enrichment of clinical trials in preclinical Alzheimers disease. Alzheimers & Dementia: The Journal of the Alzheimers Association. May;21(5):e70209.
- Bellaver B, De Bastiani MA, Brum WS, Souza DG, Ferreira PCL, Rocha AS, Povala G, Ferrari-Souza JP, Benedet AL, Ashton NJ, Karikari TK, Zetterberg H, Blennow K, Rosa-Neto P, Pascoal TA, Zimmer ER (2023). Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies. Brain, Behavior, and Immunity. Mar 4;110:175-184.
- Bellaver B, Povala G, Ferreira PCL, Ferrari-Souza JP, Leffa DT, Lussier FZ, Benedet AL, Ashton NJ, Triana-Baltzer G, Kolb HC, Tissot C, Therriault J, Servaes S, Stevenson J, Rahmouni N, Lopez OL, Tudorascu DL Villemagne VL, Ikonomovic MD, Gauthier S, Zimmer ER, Zetterberg H, Blennow K, Aizenstein HJ, Klunk WE, Snitz BE, Maki P, Thurston RC, Cohen AD, Ganguli M, Karikari TK, Rosa-Neto P, Pascoal TA. Astrocyte reactivity influences the association of amyloid- and tau biomarkers in preclinicalAlzheimers disease (2023). Nature Medicine. May 29 doi: 10.1038/s41591-023-02380-x.
- Bellaver B, Puig-Pijoan A, Ferrari-Souzaa JP, Leffa DT, Lussier FZ, Ferreira PCL, Tissot C, Povala G, Therriault J, Benedet AL, Ashton NJ, Servaes S, Chamoun M, Stevenson J, Rahmouni N, Vermeiren M, Macedo AC, Fernndez-Lebrero A, Garca-Escobar G, Navalpotro-Gmezc I, Lopez O, Tudorascu DL, Cohen A, Villemagne VL, Klunk WE, Gauthier S, Zimmer ER, Karikari TK, Blennow K, Zetterberg H, Surez-Calvet M, Rosa-Neto P, Pascoal TA (2023). Blood-brain barrier integrity impacts the use of plasma amyloid- as a proxy of brain amyloid- pathology. Alzheimers & Dementia: The Journal of the Alzheimers Association. Sep;19(9):3815-3825.
- Ferrari-Souza JP, Ferreira PCL, Bellaver B, Tissot C, Wang YT, Leffa DT, Brum WS, Benedet AL, Ashton NJ, De Bastiani MA, Rocha A, Therriault J, Lussier FZ, Chamoun M, Servaes S, Bezgin G, Kang MS, Stevenson J, Rahmouni N, Pallen V, Poltronetti NM, Klunk WE, Tudorascu DL, Cohen AD, Villemagne VL, Gauthier S, Blennow K, Zetterberg H, Souza DO, Karikari TK, Zimmer ER, Rosa-Neto P, Pascoal TA. Astrocyte biomarker signatures of amyloid- and tau pathologies in Alzheimer's disease (2022). Mol.Psychiatry. Nov;27(11):4781-4789.
Clinical Interests
Selected Clinical Publications & Products- Pascoal TA, Aguzzoli CS, Lussier FZ, Crivelli L, Suemoto CK, Fortea J, Rosa-Neto P, Zimmer ER, Ferreira PCL, Bellaver B (2024). Insights into the use of biomarkers in clinical trials in Alzheimer's disease. EBiomedicine. Oct;108:105322.
- Bieger A, Rocha AS, Bellaver B, Machado L, Da Ros L, Borelli WV, Therriault J, Macedo AC, De Bastiani MA, Pascoal TA, Gauthier S, Rosa-Neto P, Zimmer ER (2023). Neuroinflammation biomarkers in the AT(N) framework across the Alzheimers disease continuum. J Prev Alzheimers Dis. 10(3):401-417.
