Faculty

Henry W Chase, PhD

Research Assistant Professor of Psychiatry

Contact Details

3811 O'Hara St.
Pittsburgh
 
PA
 
15213
Email

Education & Training

PhD
Experimental Psychology, University of Cambridge
Psychiatry, University of Pittsburgh School of Medicine
Experimental Psychology, University of Nottingham

Professional Affiliations

Member, Society of Biological Psychiatry

Research Interests

Computational analysis of behavioral performance; Task-based & resting state neuroimaging analysis; Multivariate analysis techniques
Selected Research Publications & Products
  1. Chase HW, Hafeman DM, Ghane M, Skeba A, Brady T, Aslam HA, Stiffler R, Bonar L, Graur S, Bebko G, Bertocci M, Iyengar S, Phillips ML. Reproducible Effects of Sex and Acquisition Order on Multiple Global Signal Metrics: Implications for Functional Connectivity Studies of Phenotypic Individual Differences Using fMRI. Brain and Behavior, (2025). 15(4), e70141.
  2. Schumer MC, Chase HW, Rozovsky R, Eickhoff SB, Phillips ML. Prefrontal, parietal, and limbic condition-dependent differences in bipolar disorder: a large-scale meta-analysis of functional neuroimaging studies. Molecular psychiatry, (2023) 28(7), 2826-2838.
  3. Chase HW. A novel technique for delineating the effect of variation in the learning rate on the neural correlates of reward prediction errors in model-based fMRI. Frontiers in Psychology, (2023). 14, 1211528.
  4. Chase HW, Boudewyn MA, Carter CS, Phillips ML. Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation. Molecular psychiatry, (2020). 25(2), 397-407.
  5. Chase HW, Grace AA, Fox PT, Phillips ML, Eickhoff SB. Functional differentiation in the human ventromedial frontal lobe: A data-driven parcellation. Human Brain Mapping, (2020). 41(12):3266-3283.

Clinical Interests

Mood disorders; Neurophysiologcial interventions; Neurophysiological biomarker discovery

Education Interests

Graduate & undergraduate research mentorship

Pitt Psychiatry Hosts Second Annual Interventional Psychiatry Showcase

Collage of Interventional Psychiatry Showcase

In interventional psychiatry research, investigators marry technology development with new knowledge of alterations in neural circuitry in psychiatric disorders. The 2025 Department of Psychiatry Interventional Psychiatry Showcase, attended by faculty, staff, and trainees, focused on transcranial direct current stimulation (tDCS) and transcranial focused ultrasound (tFUS). Through lively lunchtime roundtables...

JAMA Psychiatry: Left Ventrolateral Prefrontal Cortical Activity During Reward Expectancy and Mania Risk

Drs. Manan Arora and Mary Phillips

Mania/hypomania is characterized by elevated reward sensitivity and goal overvaluation, impulsivity, and sensation seeking, and is the defining symptom of bipolar disorder. However, in individuals without a clear history of mania/hypomania, bipolar disorder is often misdiagnosed as major depressive disorder. Replicable neural markers of mania/hypomania risk are needed for earlier bipolar diagnosis, as well as for...

Pitt Psychiatry Establishes Center for Neural Circuit-Based Technology Interventions in Psychiatry

Faculty of the New CNCTI-P Center

The Department of Psychiatry has established a Center for Neural Circuit-Based Technology Interventions in Psychiatry (CNCTI-P), which will be led by Mary Phillips, MD, MD (CANTAB) (Distinguished Professor of Psychiatry, Clinical and Translational Science, and Bioengineering, and Pittsburgh Foundation-Emmerling Endowed Chair in Psychotic Disorders). Dr. Phillips is an international leader in affective neuroscience...

Psychiatry Research: Neural Markers of Mania That Distinguish Inpatient Adolescents with Bipolar Disorder from Those with Other Psychopathology

Drs. Rasim Diler and Michele Bertocci

Adolescents with manic or hypomanic episodes—key features of bipolar disorder (BD)—may experience delayed correct diagnosis or inappropriate treatment because some symptoms of BD are also seen in other disorders (such as unipolar depressive disorders and attention deficit/hyperactive disorder). A team of scientists from the University of Pittsburgh including Michele Bertocci, PhD (Assistant Professor of Psychiatry)...

JAMA Psychiatry: Patterns of Neural Network Functional Connectivity Associated With Mania/Hypomania and Depression Risk in 3 Independent Young Adult Samples 

Drs. Maya Schumer and Mary Phillips

Bipolar disorder, which has peak onset in early adulthood, is often difficult to accurately diagnose due to misreporting mania/hypomania, even though mania/hypomania is a pathognomonic feature of the disorder. The misreporting of this feature frequently results in mistaking bipolar disorder for unipolar depression. To facilitate earlier and accurate bipolar disorder diagnoses, there is a vital need for objective...