Melanie J Grubisha, MD, PhD

Associate Professor of Psychiatry

Areas of Expertise

  • Psychosis
  • Emergency & Crisis
  • Consultation-Liaison
  • Basic & Translational Neuroscience
Melanie J Grubisha
Expertise & Interests Selected Publications Education & Credentials Related News

Expertise & Interests

Research Interests

Dendritic alterations in schizophrenia; Dendritic regression pathways

Clinical Interests

Community crisis management; Psychosis; Consultation and liaison psychiatry

Education Interests

Medical student and resident education; Research mentorship

Selected Publications

  1. Parnell E, Christiansen JM, Spratt MA, Ruiz S, Macdonald ML, Penzes P, Sweet RA & Grubisha, MJ. Oligodendrocyte myelin glycoprotein impairs dendritic arbors via schizophrenia risk gene Trio. Neurobiol Dis. 2025 April; Epub ahead of print. https://doi.org/10.1016/j.nbd.2025.106928
  2. Lyu J, MacDonald ML, Gilardi J, Buchwald SC, Grubisha MJ & Sweet RA. Deciphering the alteration of MAP2 interactome caused by a schizophrenia-associated phosphorylation. Neurobiol Dis. 2024 Dec; 203:106731: Epub 2024 Nov 10. PMID 39532265
  3. Grubisha MJ. Sun T, Eisenman L, Erickson SL, Chou S, Helmer CD, Trudgen MT, Ding Y, Homanics GE, Penzes P, Wills ZP & Sweet RA. A Kalirin missense mutation enhances dendritic RhoA signaling and leads to regression of cortical dendritic arbors across development. PNAS. 2021 Dec 7;118(49): PMID: 34848542 PMCID: PMC8694055
  4. Grubisha M, Wilson J, Gopalan P & Azzam P. Suspected secondhand smoke and clozapine toxicity. Psychosomatics. 2015 Nov-Dec;56(6):707-9.
  5. Grubisha MJ, Brennan JL & Douaihy A. Isolated sinus tachycardia following reinitiation of risperidone in a patient with suspected autonomic hypersensitivity. J Pharmacol Pharmacother. 2015 Jan-Mar;6(1):42-4 PMCID: PMC4319250
  6. Grubisha M, Gopalan P & Azzam PN. Takotsubo cardiomyopathy in a young man after maintenance electroconvulsive therapy and clozapine initiation: A case report. The Journal of ECT. 2014 Dec; 30(4):e40-1.

Education & Credentials

Education & Training

Education
MD, University of Pittsburgh, School of Medicine
Education
PhD, Molecular Pharmacology and Chemical Biology, University of Pittsburgh, School of Medicine
Residency
Psychiatry, UPMC Western Psychiatric Hospital
Postdoctoral
Training in Transformative Discovery in Psychiatry, University of Pittsburgh School of Medicine

Selected Honors & Awards

  • \This Stuff Is Really Cool\" Effective Scientific Communication Workshop Award, Society of Biological Psychiatry
  • Outstanding Resident Award, National Institute of Mental Health
  • Research Colloquium for Junior Investigators, American Psychiatric Association"

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