Matthew L MacDonald, PhD

Associate Professor of Psychiatry

Areas of Expertise

  • Older Adults
  • Psychosis
  • Basic & Translational Neuroscience
  • Neurodevelopmental Disorders
Matthew L MacDonald, PhD
Expertise & Interests Selected Publications Education & Credentials Related News

Expertise & Interests

Research Interests

Proteomics and protein networks; Schizophrenia relevant spine biology; Protein network alterations in schizophrenia

Education Interests

Research mentoring; Graduate student education

Selected Publications

  1. Krivinko JM, Fan P, Sui Z, Happe C, Hensler C, Gilardi J, Ikonomovic MD, McKinney BC, Newman J, Ding Y, Wang L, Sweet RA, MacDonald ML. Age-related loss of large dendritic spines in the precuneus is statistically mediated by proteins which are predicted targets of existing drugs. Mol Psychiatry. 2025 May;30(5):2059-2067. doi: 10.1038/s41380-024-02817-w. Epub 2024 Nov 13. PMID: 39537705.
  2. Dumrongprechachan V, Salisbury RB, Butler L, MacDonald ML, Kozorovitskiy Y. Dynamic proteomic and phosphoproteomic atlas of corticostriatal axons in neurodevelopment. Elife. 2022 Oct 14;11:e78847. doi: 10.7554/eLife.78847. PMID: 36239373; PMCID: PMC9629834.
  3. Dumrongprechachan V, Salisbury RB, Soto G, Kumar M, MacDonald ML, Kozorovitskiy Y. Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum. Nat Commun. 2021 Aug 11;12(1):4855. doi: 10.1038/s41467-021-25144-y. PMID: 34381044; PMCID: PMC8357913.
  4. MacDonald ML, Garver M, Newman J, Sun Z, Kannarkat J, Salisbury R, Glausier J, Ding Y, Lewis DA, Yates N, Sweet RA. Synaptic proteome alterations in the primary auditory cortex of schizophrenia. JAMA Psychiatry. 2019 Oct 23:1-10. PMID: 31642882.
  5. MacDonald ML, Alhassan J, Newman JT, Richard M, Gu H, Kelly RM, Sampson AR, Fish KN, Penzes P, Wills ZP, Lewis DA, Sweet RA. Selective loss of smaller spines in schizophrenia. Am J Psychiatry. 2017 Jun 1;174(6):586-594. doi: 10.1176/appi.ajp.2017.16070814. Epub 2017 Mar 31. PMID: 28359200; PMCID: PMC5800878.

Education & Credentials

Education & Training

Education
PhD, Pharmacology, University of Pennsylvania, School of Medicine
Postdoctoral
Psychiatry, University of Pittsburgh School of Medicine

Professional Affiliations

  • Member, Society for Neuroscience
  • Member, American Society for Mass Spectrometry

Selected Honors & Awards

  • NARSAD Young Investigator Award, Brain & Behavior Research Foundation

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