Education & Training
Selected Honors & Awards
- Liu Z, Wang Y, Cai Li, Li Yizhi, Chen B, Dong Y, Huang YH (2016) Prefrontal cortex to accumbens projections in sleep regulation of reward. J Neurosci 36: 7897-7910 *Featured article.
- Chen B, Wang Y, Liu X, Liu Z, Dong Y, Huang YH (2015) Sleep regulates incubation of cocaine craving. J Neurosci 35: 13300-13310. *Featured article.
- Ma YY, Lee BR, Wang X, Guo C, Liu L, Cui R, Lan Y, Balcita-Pedicino JJ, Wolf ME, Sesack SR, Shaham Y, Schlter OM, Huang YH, Dong Y (2014) Bi-directional modulation of incubation of cocaine craving by silent synapse-based remodeling of prefrontal cortex to accumbens projections. Neuron 83:1453-1467.
- Lee BR, Ma YY, Huang YH, Wang X, Otaka M, Ishikawa M, Neumann PA, Graziane NM, Brown TE, Suska A, Guo C, Lobo MK, Sesack SR, Wolf ME, Nestler EJ, Shaham Y, Schlter OM, Dong Y (2013) Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving. Nat Neurosci 16:1644-1651.
- Huang YH, Lin Y, Mu P, Lee BR, Brown TE, Wayman G, Marie H, Liu W, Yan Z, Sorg BA, Schlter OM, Zukin RA, Dong Y (2009) In vivo cocaine experience generates silent synapses. Neuron 63:40-47.
Department Faculty Highlight the Role of Adolescent Sleep and Circadian Rhythm Disruptions in Risk of Substance Use Disorders
Sleep and circadian rhythms, the 24-hour cycles of the body’s physiological processes, are important components of health. Likewise, disruptions in these systems are linked to a number of health conditions, including substance abuse. The developmental changes in sleep and circadian rhythms that occur during adolescence leave teenagers particularly vulnerable to addiction. A review recently published in the journal...
Translational Neuroscience Program Faculty Show Circadian Rhythms Regulate Reward through Metabolic Signaling in the Brain
Circadian rhythms are near 24-hour oscillations controlling many aspects of physiology and behavior. The coordination and orchestration of these rhythms maintain homeostasis throughout the body. Evidence from humans suggests disruptions to circadian rhythms and sleep are linked to several psychiatric disorders, including substance use and abuse disorders. Indeed, several human and animal studies have demonstrated...
Yanhua Huang, PhD Promoted to Associate Professor by Pitt School of Medicine
Yanhua Huang, PhD has focused her research on neural plasticity within the reward circuitry of the brain. She studies molecular and cellular mechanisms underlying drug abuse and addiction and sleep-mediated regulation of reward-elicited behaviors. By studying neural plasticity in rodent models, she is working to characterize pathway-specific changes in the reward circuitry of the brain following sleep disturbances...
Drs. Colleen A. McClung and Yanhua Huang Find That Nucleus Accumbens Excitatory Signaling Is Integral to Effects of Clock Gene Disruption on Manic-like Behaviors
Disruptions in circadian rhythms are associated with an increased risk for bipolar disorder, and the circadian protein CLOCK is involved in regulating monoaminergic systems and mood-related behavior. Colleen A. McClung, PhD , Professor of Psychiatry and Yanhua Huang, PhD , Assistant Professor of Psychiatry set out to clarify the molecular and synaptic mechanisms underlying this relationship. Working in...