Tharick Pascoal, MD, PhD

Associate Professor of Psychiatry and Neurology

Areas of Expertise

  • Older Adults
Tharick Pascoal, MD, PhD
Expertise & Interests Selected Publications Education & Credentials Related News

Expertise & Interests

Research Interests

Alzheimer's disease and related dementias; Biomarkers; Aging

Clinical Interests

Alzheimer's disease and related dementias; Cognitive disorders

Selected Publications

  1. Rohden F, Ferreira PCL, Bellaver B, Ferrari-Souza JP, Aguzzoli CS, Soares C, Abbas S, Zalzale H, Povala G, Lussier FZ, Leffa DT, Bauer-Negrini G, Rahmouni N, Tissot C, Therriault J, Servaes S, Stevenson J, Benedet AL, Ashton NJ, Karikari TK, Tudorascu DL, Zetterberg H, Blennow K, Zimmer ER, Souza D, Rosa-Neto P, Pascoal TA. Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer's disease. Nat Commun. 2025 Jul 1;16(1):5653. doi: 10.1038/s41467-025-60806-1. PMID: 40593718 Free PMC article.
  2. Leffa DT, Povala G, Bellaver B, Ferrari-Souza JP, Ferreira PCL, Lussier FZ, Schaffer Aguzzoli C, Soares C, Zalzale H, Rohden F, Bauer-Negrini G, Abbas S, Schneider M, Therriault J, Lopez OL, Villemagne VL, Klunk WE, Tudorascu DL, Cohen AD, Rosa-Neto P, Zimmer ER, Karikari TK, Rohde LA, Molina BSG, Pascoal TA, Alzheimer's Disease Neuroimaging Initiative. Impact of the polygenic risk scores for attention-deficit/hyperactivity disorder in Alzheimer's disease. Alzheimers Dement. 2025 Feb;21(2):e70003. doi: 10.1002/alz.70003.PMID: 39998851 Free PMC article.
  3. Bellaver B, Povala G, Ferreira PCL, Ferrari-Souza JP, Leffa DT, Lussier FZ, Benedet AL, Ashton NJ, Triana-Baltzer G, Kolb HC, Tissot C, Therriault J, Servaes S, Stevenson J, Rahmouni N, Lopez OL, Tudorascu DL, Villemagne VL, Ikonomovic MD, Gauthier S, Zimmer ER, Zetterberg H, Blennow K, Aizenstein HJ, Klunk WE, Snitz BE, Maki P, Thurston RC, Cohen AD, Ganguli M, Karikari TK, Rosa-Neto P, Pascoal TA. Astrocyte reactivity influences amyloid- effects on tau pathology in preclinical Alzheimer's disease. Nat Med. 2023 May 29;. doi: 10.1038/s41591-023-02380-x. PMID: 37248300.
  4. Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P. Microglial activation and tau propagate jointly across Braak stages. Nat Med. 2021 Sep;27(9):1592-1599. doi: 10.1038/s41591-021-01456-w. Epub 2021 Aug 26. PubMed PMID: 34446931.
  5. Ferrari-Souza JP, Bellaver B, Ferreira PCL, Benedet AL, Povala G, Lussier FZ, Leffa DT, Therriault J, Tissot C, Soares C, Wang YT, Chamoun M, Servaes S, Macedo AC, Vermeiren M, Bezgin G, Kang MS, Stevenson J, Rahmouni N, Pallen V, Poltronetti NM, Cohen A, Lopez OL, Klunk WE, Soucy JP, Gauthier S, Souza DO, Triana-Baltzer G, Saad ZS, Kolb HC, Karikari TK, Villemagne VL, Tudorascu DL, Ashton NJ, Zetterberg H, Blennow K, Zimmer ER, Rosa-Neto P, Pascoal TA. APOEe4 potentiates amyloid effects on longitudinal tau pathology. Nat Aging. 2023 Oct;3(10):1210-1218. doi: 10.1038/s43587-023-00490-2. Epub 2023 Sep 25. PubMed PMID: 37749258.
  6. Pascoal TA, Aguzzoli CS, Lussier FZ, Crivelli L, Suemoto CK, Fortea J, Rosa-Neto P, Zimmer ER, Ferreira PCL & Bellaver B. Insights into the use of biomarkers in clinical trials in Alzheimer's disease. EBioMedicine. 2024 Oct;108:105322. doi: 10.1016/j.ebiom.2024.105322. Epub 2024 Oct 3. Review. PubMed PMID: 39366844.
  7. Pascoal TA, Chamoun M, Mohades S, Shin M, Wu L, Gauthier S, et al. Siblings with a fatal cause of rapidly progressive dementia. Case Studies in Dementia: Common and Uncommon Presentations. 2nd ed. New York: Cambridge University Press; 2021a. p. 136.
  8. Pascoal TA, Shin M, Chamoun M, Gauthier S & Rosa-Neto P. A devoted wife with an atypical finding. Case Studies in Dementia: Common and Uncommon Presentations. 2nd ed. New York: Cambridge University Press; 2021b. P. 18.
  9. Rosa-Neto P, Gauthier S & Pascoal TA. Predicting Alzheimers disease dementia: It takes two to tango. World Alzheimers Report Global Perspective, March 2017
  10. Pascoal TA, Cohen A & Villemagne V. Tau PET for the diagnosis and staging of Alzheimers disease. World Alzheimers Report 2021: journey through the diagnosis of dementia

Education & Credentials

Education & Training

Education
MD, Federal University of Pelotas, Brazil
Education
PhD, Neuroscience, McGill University
Residency
Neurology, Pontifical Catholic University of Rio Grande do Sul, Brazil
Fellowship
Neurodegenerative Diseases, Douglas Hospital, McGill University
Postdoctoral
Neuroscience, McGill University

Professional Affiliations

  • Member, American Academy of Neurology
  • Member, Alzheimer's Association's International Society to Advance Alzheimer's Research and Treatment

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