Neal D Ryan, MD

Joaquim Puig-Antich Professor in Child and Adolescent Psychiatry and Professor of Psychiatry and Clinical and Translational Science

Areas of Expertise

  • Children & Adolescents
  • Mood Disorders
  • Anxiety, OCD & Trauma Disorders
Expertise & Interests Selected Publications Education & Credentials Related News

Expertise & Interests

Research Interests

Machine learning and big data in psychiatry

Clinical Interests

Childhood/adolescent depression & anxiety

Education Interests

Research mentorship of early career faculty; Research design mentoring; Machine learning and big data in psychiatry

Selected Publications

  1. Westbrook CA, Schlund M, Silk JS, Forbes EE, Ryan ND, Dahl RE, McMakin DL, Kendall PC, Mannarino A, Ladouceur CD. The role of reward-related brain activity in response to treatment and later depression severity: data from a randomized controlled trial in early adolescents with anxiety disorders. Transl Psychiatry. 2025 Aug 16;15(1):286. doi: 10.1038/s41398-025-03388-2. PMID: 40818984; PMCID: PMC12357957.
  2. Miranda O, Kiehl S, Qi X, Ryan ND, Kirisci L, Brannock MD, Kosten T, Wang Y, Wang L. Enhancing post-traumatic stress disorder patient assessment: Leveraging Natural Language Processing for Research of Domain Criteria Identification using electronic medical records. Res Sq [Preprint]. 2024 Feb 21:rs.3.rs-3973337. doi: 10.21203/rs.3.rs-3973337/v1. Update in: BMC Med Inform Decis Mak. 2024 Jun 4;24(1):154. doi: 10.1186/s12911-024-02554-8. PMID: 38464073; PMCID: PMC10925404.
  3. Gupta T, Eckstrand KL, Lenniger CJ, Haas GL, Silk JS, Ryan ND, Phillips ML, Flores LE Jr, Pizzagalli DA, Forbes EE. Anhedonia in adolescents at transdiagnostic familial risk for severe mental illness: Clustering by symptoms and mechanisms of association with behavior. J Affect Disord. 2024 Feb 15;347:249-261. doi: 10.1016/j.jad.2023.11.062. Epub 2023 Nov 21. PMID: 37995926; PMCID: PMC10843785.
  4. Han S, Zhang RF, Shi L, Richie R, Liu H, Tseng A, Quan W, Ryan N, Brent D, Tsui FR. Classifying social determinants of health from unstructured electronic health records using deep learning-based natural language processing. J Biomed Inform. 2022 Mar;127:103984. doi: 10.1016/j.jbi.2021.103984. Epub 2022 Jan 7. PMID: 35007754.
  5. Tsui FR, Shi L, Ruiz V, Ryan ND, Biernesser C, Iyengar S, Walsh CG, Brent DA. Natural language processing and machine learning of electronic health records for prediction of first-time suicide attempts. JAMIA Open. 2021 Mar 17;4(1):ooab011. doi: 10.1093/jamiaopen/ooab011. PMID: 33758800; PMCID: PMC7966858.
  6. Saunders J, Gopalan P, Puri N, Azzam PN, Zhou L, Ghinassi F, Jain A, Travis M, Ryan ND. Psychosomatic Medicine for Non-Psychiatric Residents: Video Educationand Incorporation of Technology. Acad Psychiatry. 2015 Dec;39(6):649-53. doi:10.1007/s40596-015-0311-3. Epub 2015 Mar 31. PubMed PMID: 25825227.
  7. Jacobson SL, Travis MJ, Solai L, MacPhee E, Reynolds CF 3rd, Ryan ND, Roth LH, Kupfer DJ. Preparing the next generation of leaders in clinician-education andacademic administration. Acad Psychiatry. 2010 May-Jun;34(3):224-8. doi:10.1176/appi.ap.34.3.224. PubMed PMID: 20431105.
  8. Gilbert AR, Tew JD Jr, Reynolds CF 3rd, Pincus HA, Ryan N, Nash K, Kupfer DJ. A developmental model for enhancing research training during psychiatry residency. Acad Psychiatry. 2006 Jan-Feb;30(1):55-62. PubMed PMID: 16473996.
  9. Reynolds CF 3rd, Martin C, Brent D, Ryan N, Dahl RE, Pilkonis P, Marcus MD, Kupfer DJ. Postdoctoral clinical-research training in psychiatry: A model for teaching grant writing and other research survival skills and for increasingclarity of mentoring expectations. Acad Psychiatry. 1998 Sep;22(3):190-6. doi:10.1901/jaba.1998.22-190. PubMed PMID: 19617924; PubMed Central PMCID:PMC2711541.

Education & Credentials

Education & Training

Education
MD, Yale University, School of Medicine
Residency
Psychiatry, New York State Psychiatric Institute, Columbia University
Fellowship
Child Psychiatry, Western Psychiatric Institute and Clinic of UPMC

Professional Affiliations

  • Fellow, American Academy of Child and Adolescent Psychiatry
  • Member, American College of Neuropsychopharmacology
  • Member, Society of Biological Psychiatry

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