Nadine Melhem, PhD

Professor of Psychiatry and Clinical and Translational Science

Areas of Expertise

  • Children & Adolescents
  • Mood Disorders
  • Anxiety, OCD & Trauma Disorders
  • Basic & Translational Neuroscience
  • Suicidality & Self-Harm
Nadine Melhem, PhD
Expertise & Interests Selected Publications Education & Credentials Related News

Expertise & Interests

Research Interests

Neurobiology of stress & suicide; Peripheral and neural biomarkers; Children, adolescents & young adults

Clinical Interests

Stress response and suicide

Education Interests

Mentoring undergraduate and graduate students; Mentoring medical students; Mentoring postdoctoral and visiting fellows

Selected Publications

  1. Herzog S, Bartlett EA, Zanderigo F, Galfalvy HC, Burke A, Mintz A, Schmidt M, Hauser E, Huang YY, Melhem N, Sublette ME, Miller JM, Mann JJ. Neuroinflammation, stress-related suicidal ideation, and negative mood in depression. JAMA Psychiatry. 2025 Jan1;82(1):85-93. Pubmed PMID: 39504032
  2. Melhem N, Moutier CY, Brent DA. Implementing evidence-vased suicide prevention strategies for greatest impact. Focus (Am Psychiatr Publ). 2023 Apr;21(2):117-128. PubMed PMID: 37201145
  3. Melhem NM, Zhong Y, Miller JM, Zanderigo F, Ogden T, Sublette ME, Newell M, Burke A, Keilp JG, Lesanpezeshki M, Bartlett E, Brent DA, Mann JJ. Brain 5-HT1A Receptor PET Binding, Cortisol responses to stress, and the familial transmission of suicidal behavior. Int J Neuropsychopharmacol. 2022 Jan 12;25(1):36-45. PubMed PMID: 34555145
  4. Hayes B, Brent J, Zhong Y, Bazmi S, Porta G, Bovbjerg D, Tarhini A, Kirkwood JM, Brent D, Marsland A, Melhem NM. Early cortisol and inflammatory responses to parental cancer and their impact on functional impairment in youth. J Clin Med. 2021 Feb 4;10(4):576. PubMed PMID: 33557083
  5. Melhem NM, Porta G, Oquendo M, Zelazny J, Keilp J, Iyengar S, Burke A, Birmaher B, Stanely B, Mann J, Brent D. Severity and variability of depression symptoms predict suicide attempt. JAMA Psychiatry. 2019 Jun;76(6):603-613. PubMed PMID:30810713
  6. Inventory for Complicated Grief- Revised for Children (ICG-RC). An instrument and screen with established cut-offs developed to measure grief reactions in children. Citation: Melhem NM, Porta G, Walker Payne M, Brent DA. Identifying prolonged grief reactions in children: Dimensional and diagnostic approaches. J Am Acad Child Adolesc Psychiatry 2013 Jun;52(6):599-607. PubMed PMID: 23702449

Education & Credentials

Education & Training

Education
PhD, Psychiatric Epidemiology, University of Pittsburgh, Graduate School of Public Health
Education
MPH, Epidemiology and Biostatistics, American University of Beirut

Selected Honors & Awards

  • NARSAD Young Investigator Award, Brain & Behavior Research Foundation
  • John & Nancy Emerling Fund Young Investigator Award, Pittsburgh Foundation
  • NARSAD Young Investigator Award, Brain & Behavior Research Foundation
  • Young Investigator Award, American Foundation for Suicide Prevention

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