Marianne L Seney, PhD

Associate Professor of Psychiatry and Bioengineering

Areas of Expertise

  • Anxiety, OCD & Trauma Disorders
  • Mood Disorders
  • Basic & Translational Neuroscience
Marianne L Seney, PhD

Expertise & Interests

Research Interests

Sex differences in psychiatric disorders; Dendritic spine/microglia alterations; depression; Molecular rhythm disruptions in brain disorders

Education Interests

Research mentorship

Selected Publications

  1. Shelton MA, Horan N, Xue X, Maturin L, Eacret D, Michaud J, Singh N, Williams BR, Gamble MC, Seggio JA, Fish MK, Phan BN, Tseng GC, Blendy JA, Solberg Woods LC, Palmer AA, George O, Logan RW, Seney ML. Sex-specific concordance of striatal transcriptional signatures of opioid addiction in human and rodent brains. Biol Psychiatry Glob Open Sci. 2025 Feb 26;5(3):100476. doi: 10.1016/j.bpsgos.2025.100476. PMID: 40248277.
  2. Yoblinski AR, Dubey J, Myers T, Sathees N, Volk DW, Fish KN, Seney ML. Brain region and sex differences in human microglia morphology and function. Cereb Cortex. 2025 May 1;35(5):bhaf120. doi: 10.1093/cercor/bhaf120. PMID: 40420495.
  3. Jenkins AK, Shelton MA, Yin R, Gorczyca MT, Zong W, Glausier JR, Lewis DA, Tseng GC, Seney ML, McClung CA. Disentangling transcriptomic heterogeneity within the human subgenual anterior cingulate cortex. Cereb Cortex. 2024 Jul 3;34(7):bhae291. doi: 10.1093/cercor/bhae291. PMID: 39051661.
  4. Phan BN, Ray MH, Xue X, Fu C, Fenster RJ, Kohut SJ, Bergman J, Haber SN, McCullough KM, Fish MK, Glausier JR, Su Q, Tipton AE, Lewis DA, Freyberg Z, Tseng GC, Russek SJ, Alekseyev Y, Ressler KJ, Seney ML, Pfenning AR, Logan RW. Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder. Nat Commun. 2024 Jan 31;15(1):878. doi: 10.1038/s41467-024-45165-7. PMID: 38296993.
  5. Logan RW, Xue X, Ketchesin KD, Hoffman G, Roussos P, Tseng G, McClung CA, Seney ML. Sex differences in molecular rhythms in the human cortex. Biol Psychiatry. 2022 Jan 1;91(1):152-162. doi: 10.1016/j.biopsych.2021.03.005. Epub 2021 Mar 8. PMID: 33934884.

Education & Credentials

Education & Training

Education
PhD, Neuroscience and Behavior, University of Massachusetts

Professional Affiliations

  • Associate Member, American College of Neuropsychopharmacology
  • Member, Society of Biological Psychiatry
  • Member, International Behavioral Neuroscience Society
  • Member, Society for Neuroscience
  • Member, Organization for the Study of Sex Differences

Selected Honors & Awards

  • Honorable Mention, Ziskind-Somerfeld Research Award, Society of Biological Psychiatry
  • Hamilton Family Award for Basic Neuroscience Research in Psychiatry, University of Pittsburgh School of Medicine
  • NARSAD Young Investigator Award, Brain & Behavior Research Foundation
  • NARSAD Young Investigator Award, Brain & Behavior Research Foundation
  • Elected Young Investigator Councilor, Organization for the Study of Sex Differences