Kadiamada N Chengappa, MD

Professor of Psychiatry

Current Appointments

  • Chief, Comprehensive Recovery Service

Areas of Expertise

  • Psychosis
Kadiamada N Chengappa, MD
Expertise & Interests Selected Publications Education & Credentials Related News

Expertise & Interests

Research Interests

Ashwagandha for schizophrenia; Negative symptoms & cognition; Insulin resistance & mental illness

Clinical Interests

Treatment of serious mental illness; Quality improvement projects; Deprescription of medications

Education Interests

Mentoring residents & junior faculty; Shared decision making; Continuing education

Selected Publications

  1. Calkin CV, Chengappa KNR, Cairns K, Cookey J, Gannon JM, Alda M, ODonovan C, Reardon C, Sanches M, Ruzickova M. Treating insulin-resistance with metformin as a strategy to improve clinical outcomes in treatment-resistant bipolar depression: A randomized, quadruple-masked, placebo-controlled clinical trial (The TRIO-BD Study). J Clin Psychiatry 2022;83(2):m14022. PMID: 35120288. (Awarded the Paul Wender Best Paper in the Journal of Clinical Psychiatry by the American Society of Clinical Psychopharmacology)
  2. Lupu AM, MacCamy K, Gannon J, Brar J, Chengappa KNR. Less is more: Deprescribing anticholinergic medications in persons with severe mental illness. Ann Clin Psychiatry. 2021 Feb 1;33(1):e1-e13. doi: 10.12788/acp.0019. PMID: 33529289. (Awarded the George Winokur Clinical Research Paper Award by American Academy of Clinical Psychiatrists)
  3. Chengappa KNR, Brar JS, Gannon JM, Schlicht PJ. Adjunctive use of a standardized extract of Withania somnifera (Ashwagandha) to treat symptom exacerbation in Schizophrenia: A Randomized, Double-blind, Placebo-controlled study. J Clin Psychiatry 2018;79(5):43-51. PMID: 29995356
  4. Chengappa KNR, Perkins KA, Brar JS, Schlicht PJ, Turkin SR, Hetrick ML, Levine MD, George TP. Varenicline for smoking cessation in bipolar disorder: A double-blind, random assignment, placebo controlled study. J Clin Psychiatry. 2014; 75:765-772. PMID: 25006684 (Awarded the Paul Wender Best Paper in the Journal of Clinical Psychiatry by the American Society of Clinical Psychopharmacology)
  5. United States Patent - Methods and Compositions for Treating Schizophrenia and Schizophrenia Disorders No.: US 11,219,659, B2 Chengappa et al. January 11, 2022 https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/11219659
  6. Gershon S, Chengappa KNR. Contemporary diagnosis and management of bipolar disorders. 2009. Handbooks in Health Care Co., Newtown, PA, USA.
  7. Goldberg JF, Chengappa KNR. Identifying and treating cognitive impairment in bipolar disorder. Bipolar Disorders. 2009;11(2): 123-137. PMID: 19538691
  8. Chengappa KNR, Schwarzman L, Hulihan JF, Xiang J, Rosenthal NR, for the CAPSS-168 Investigators. Adjunctive topiramate therapy in patients receiving a mood stabilizer for bipolar I disorder: a randomized, placebo-controlled trial. Journal of Clinical Psychiatry. 2006; 67:1698-1706. PMID: 17196048
  9. Chengappa KNR, Kupfer DJ, Frank E, Houck PR, Grochocinski VJ, Cluss PA, Stapf DA. The effect of birth cohort on the early age at onset of the first episode of illness in a bipolar disorder case registry. American Journal of Psychiatry. 2003; 160:1636-1642. PMID: 12944339
  10. Chengappa KNR, Ebeling T, Kang JS, Levine J, Parepally H. Clozapine reduces severe self-mutilation and aggression in psychotic patients with borderline personality disorder. Journal of Clinical Psychiatry. 1999 60:477-484. PMID 10453803
  11. Curriculum development: Clozapine curriculum for residents, fellows & attending psychiatrists
  12. Patient educational materials using Clozapine, COVID-19 and Paxlovid as a model
  13. Alam, A., Chengappa, KNR Obstructive sleep apnea and schizophrenia: A primer for psychiatrists. Acta Neuropsychiatrica 2011; 23:201-209.
  14. Less is More: Reducing the anticholinergic medication burden in patients receiving antipsychotics (Enduring Material - Video with Jessica Gannon, MD & Ana Lupu, PharmD) February 22, 2023

Education & Credentials

Education & Training

Education
MD, University of Mysore, Kasturba Medical College, Manipal
Internship
Multidisciplinary, Kasturba Medical College, Manipal
Residency
Psychiatry, Dalhousie University, Canada
Residency
Psychiatry, Edinburgh University, United Kingdom
Residency
Psychiatry, National Institute of Mental Health and Neurosciences, India
Residency
Internal Medicine and Psychiatry, Kasturba Medical College, India
Postdoctoral
Clinical Research in Schizophrenia, University of Pittsburgh School of Medicine

Professional Affiliations

  • Member, American Society for Clinical Psychopharmacology
  • Member, International Society for Bipolar Disorders
  • Member, Canadian Psychiatric Association

Selected Honors & Awards

  • Paul Wender Best Paper Award, American Society of Clinical Psychopharmacology
  • Outstanding Academician Award, Indo American Psychiatric Association
  • President's Award, Pennsylvania Community Providers Association
  • Young Investigators Award, National Institutes of Mental Health, New Clinical Drug Evaluation Unit
  • Rev. C. Leroy Hacker Ambassador Award, Mayview State Hospital

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