Joshua Krivinko, MD

Assistant Professor of Psychiatry

Areas of Expertise

  • Consultation-Liaison
  • Basic & Translational Neuroscience
  • Older Adults
Joshua Krivinko, MD
Expertise & Interests Selected Publications Education & Credentials Related News

Expertise & Interests

Research Interests

Synapse loss in aging and ADRDs; CNS drug development; Mechanisms of cognitive resilience

Clinical Interests

Neurocognitive disorders; Consultation-Liaison Psychiatry

Education Interests

Medical student and resident training

Selected Publications

  1. Krivinko JM, Fan P, Sui Z, Happe C, Hensler C, Gilardi J, Ikonomovic MD, McKinney BC, Newman J, Ding Y, Wang L, Sweet RA, MacDonald ML. Age-related loss of large dendritic spines in the precuneus is statistically mediated by proteins which are predicted targets of existing drugs. Molecular Psychiatry. 2025 May; 30(5):2059-2067. DOI: 10.1038/s41380-024-02817-w
  2. Krivinko JM, DeChellis-Marks MR, Zeng L, Fan P, Lopez OL, Ding Y, Wang L, Kofler J, MacDonald ML, Sweet RA. Targeting the post-synaptic proteome has therapeutic potential for psychosis in Alzheimer Disease. Communications Biology. June 2023; 6(1):598. DOI: 10.1038/s42003-023-04961-5
  3. Krivinko JM, Erickson SL, MacDonald ML, Garver ME, Sweet RA. Fingolimod mitigates synaptic deficits and psychosis-like behavior in APP/PSEN1 mice. Alzheimers and Dementia: Translational Research & Clinical Interventions. August 2022; 8:e12324. DOI: 10.1002/trc2.12324
  4. Krivinko JM, Erickson SL, Ding Y, Sun Z, Penzes P, MacDonald ML, Yates, NA, Ikonomovic MD, Lopez OL, Sweet RA, Kofler J. Synaptic proteome compensation and resilience to psychosis in Alzheimer Disease. American Journal of Psychiatry. Oct 2018; 175(10): 999-1009. DOI: 10.1176/appi.ajp.2018.17080858
  5. Krivinko JM, Koppel J, Savonenko A, Sweet RA. Animal models of psychosis in Alzheimer Disease. American Journal of Geriatric Psychiatry. Jan 2020; 28(1): 1-19. DOI: 10.1016/j.jagp.2019.05.009

Education & Credentials

Education & Training

Education
MD, University of Pittsburgh, School of Medicine
Residency
General Adult Psychiatry, UPMC Western Psychiatric Hospital
Fellowship
Consultation-Liaison Psychiatry, UPMC Western Psychiatric Hospital
Postdoctoral
Brain Aging, Alzheimer's Disease and Related Dementias, University of Pittsburgh School of Medicine

Selected Honors & Awards

  • Clinician Scientist Fellowship Award, Alzheimer's Association
  • Research Colloquium Junior Investigator Award, American Psychiatric Association
  • Burroughs Wellcome Scholar, University of Pittsburgh School of Medicine
  • Stewart Sell Family Physician Scientist Award, University of Pittsburgh School of Medicine

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