Events picture

SVC Seminar Series January 27, 2017, 12:00 pm - 1:00 pm Scaife Hall, Lecture Room 6

Senior Vice Chancellor Seminar Series

Metabolomics and Psychiatric Disease: NextGen Frontiers in Pathophysiology and Treatment


 Lisa Pan, MD
 Assistant Professor of Psychiatry
 Assistant Professor of Clinical and Translational Science





Join us on January 27th when Dr. Lisa Pan will deliver the first lecture in the 2017 Senior Vice Chancellor’s Research Seminar series.  Arthur S. Levine, MD, senior vice chancellor for the health sciences and John and Gertrude Petersen Dean of Medicine, will introduce Pan and lead the discussion following her lecture. 

Dr. Pan recently garnered recognition for research that identified metabolic abnormalities in patients with treatment-refractory depression and prescribed drug therapy to correct the metabolic deficiency. Her work suggests that identifying and treating metabolic deficiencies in patients with treatment-resistant depression can improve symptoms and, in some cases, lead to remission. Major depressive disorder, also referred to simply as depression, affects nearly 15 million American adults and is one of the most common mental disorders. Depression also is the cause of more than two-thirds of suicides that occur annually. At least 15 percent of patients don’t find relief from conventional treatments, such as antidepressant medications and psychotherapy.  Pan will discuss her ongoing case-control trial looking for metabolic abnormalities in adolescents and young adults with treatment-refractory depression. Although the specific metabolites involved have differed among patients, researchers have found that at least 60 percent of the patients had a deficiency in neurotransmitter metabolism, compared with none of the controls. Pan will also discuss ongoing experiments that are aimed at discovering the underlying genetic and metabolic pathophysiology of the findings to allow for better diagnosis and management of the identified metabolic disorders. 

CME Information: The Center for Continuing Education in the Health Sciences will designate the Senior Vice Chancellor’s Research Seminar as a continuing medical education activity eligible for a maximum of one hour of Category 1 credit toward the AMA Physician’s Recognition Award. Nurses and other health professionals are awarded 0.1 Continuing Education Units (CEUs).  Target Audience: Faculty and students from the University of Pittsburgh Schools of the Health Sciences, and other schools, departments, and units across campus, and Carnegie Mellon University faculty and students from the Department of Biological Sciences. The University of Pittsburgh School of Medicine, as part of the Consortium for Academic Continuing Medical Education, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Center for Continuing Education in the Health Sciences designates this continuing medical education activity for a maximum of one hour of Category 1 credit towards the AMA Physician's Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the educational activity. Nurses and other health care professionals are awarded 0.1 Continuing Education Units (CEUs). 

Disclosure Statement: In accordance with Accreditation Council for Continuing Medical Education requirements on disclosure, information about relationships of presenters with commercial interests (if any) will be included in materials that will be distributed at the time of the conference.  We encourage participation by all individuals. If you have a disability, advance notification of any special needs will help us serve you better. Please notify us of your needs at least two weeks in advance of the program. 

Disclaimer Statement: The information presented at this CME program represents the views and opinions of the individual presenters and does not constitute the opinion or endorsement of, or promotion by, the UPMC Center for Continuing Education in the Health Sciences, University of Pittsburgh Medical Center (UPMC) or Affiliates and University of Pittsburgh School of Medicine. Reasonable efforts have been taken intending for education subject matter to be presented in a balanced, unbiased fashion and in compliance with regulatory requirements. However, each program attendee must always use his/her own personal and professional judgment in considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

For information on future lectures in this series, which highlights the growing body of important research being accomplished by young investigators in the University of Pittsburgh’s Schools of the Health Sciences, please visit our website at or call the Office of Academic Affairs at 412-383-7382.