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Etienne Sibille, PhD October 14, 2011, 12:00 pm - 1:00 pm WPIC Auditorium


Department of Psychiatry Lecture Series
Meet the PI Lecture

Major Depression: An Emerging Molecular Framework for a Multi-scale Complex Disorder

Etienne Sibille, PhD
Associate Professor of Psychiatry
and Clinical and Translational Science
University of Pittsburgh School of Medicine

Etienne Sibille, PhD, was appointed to the faculty of the University of Pittsburgh School of Medicine in 2004 after training in molecular neuropsychiatry at Cornell and Columbia Universities. His research goals have consistently focused on translational research aimed at identifying the cellular and molecular bases of depression, and specifically of the mood and affect dysregulation component of the illness. Studies in the Sibille laboratory encompass parallel investigations in postmortem brains of depressed and control subjects, and in rodent genetic and environmental models. The scientific goals are to characterize the primary pathology of depression and to assess causality relationships between identified molecular changes or candidate neurotransmitter systems and mood regulation.  In addition, Dr. Sibille‚Äôs laboratory has demonstrated that biological pathways affected during aging of the human brain largely overlap with neuropsychiatric and other neurological disease pathways and may in fact promote diseases, together providing a compelling rationale for investigating aging and diseases simultaneously. These latter hypotheses are now being tested in parallel in the human postmortem brain and in large epidemiological studies of subjects at the vigor-to-frailty transition.  Dr. Sibille has been elected to the membership of the American College of Neuropsychopharmacology and has authored more than 40 scientific research articles. He is the recipient of several NIMH grants and of a NIMH Independent Scientist Award.

For more information regarding the Department of Psychiatry Lecture Series, please contact Jeanie Knox Houtsinger at