Events picture

Brain, Behavior and Cancer Seminar Series May 25, 2017, 12:00 pm - 1:00 pm UPMC Shadyside, Hillman Cancer Center, Cooper Classroom C

Seminar Series
Sponsored byThe Biobehavioral Oncology Program
University of Pittsburgh Cancer Institute

The Importance of Circadian Rhythms in Cellular Metabolism and Human Health

Colleen A. McClung, PhD
Associate Professor of Psychiatry
Translational Neuroscience Program
University of Pittsburgh Medical Center






Abstract: Nearly all physiological and cellular functions that occur in the body have a circadian rhythm.  Environmental factors like shift work, light at night, and travel across time zones disrupt these biological rhythms.  Over time, these disruptions can have serious health related consequences.  One consequence that is well documented is the increased risk for cancer.  In this talk I will discuss several of the cellular and molecular factors that link circadian rhythm disruptions to cancer and other diseases.  I will present some of our work in human postmortem brain that shows the effect of aging on molecular rhythms, as well as our work linking the molecular clock to the control of cellular oxidative stress and gene transcription. These basic links between the control of cellular metabolism and circadian rhythms are very important in human health.  

Light lunch provided. In order to ensure enough food is available, please RSVP to Darren Gilmartin(, or contact him if you need directions or additional information. The Cooper Classrooms are located on the ground level of the Hillman Cancer Center, 5115 Centre Avenue, in Shadyside.After entering the building, walk to the left past the elevators. Facing the gift shop, turn right down the hallway.Room C is the 3rd door in the lobby area on the left.

CME Faculty Disclosure. In accordance with Accreditation Council for Continuing Medical Education requirements on disclosure, information about relationships of presenters with commercial interests (if any) will be included in materials distributed at the time of the conference.Continuing Medical Education CreditThe University of Pittsburgh School of Medicine is accredited by the ACCME to provide continuing medical education for physicians. The University of Pittsburgh School of Medicine designates this educational activity for a maximum of 1.0 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded .10 continuing education units (CEUs) which are equal to 1.0 contact hours.